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Propionic Anhydride
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PRODUCT IDENTIFICATION
CAS NO. : 123-62-6
EINECS NO. : 204-638-2
FORMULA : C2H5COOCOC2H5
MOL WT. : 130.14
H.S. CODE : 2915.90
IUPAC Name: propanoyl propanoate
TOXICITY
Oral rat LD50 : 2360 mg/kg
SYNONYMS methylacetic anhydride; Propionyl oxide;Propionic Acid
Anhydride; Propanoic Anhydride; Anhydrid Kyseliny Propionove;
CHEMICAL PROPERTIES
PHYSICAL STATE : clear liquid
MELTING POINT : -45 C
BOILING POINT : 167 C
SPECIFIC GRAVITY : 1.01
SOLUBILITY IN WATER Insoluble (decomposes slowly) pH
VAPOR DENSITY : 4.5
AUTOIGNITION : 285 C
NFPA RATINGS Health: 3 Flammability: 2 Reactivity: 1
REFRACTIVE INDEX : 1.403 - 1.405
FLASH POINT : 63 C
STABILITY : Stable under ordinary conditions
Synonyms:
propionove;anhydridkyselinypropionove;C2H5C(O)OC(O)C2H5;Methylacetic
anhydride;methylaceticanhydride;Propanoicacid,anhydride;Propinoicanhydride;propionic;Propionic
acid anhydride;propionicacidanhydride;Propionyl
oxide;propionyloxide;PROPANOIC ANHYDRIDE;PROPIONIC
ANHYDRIDE;Propionic Anhydried;Propanic Anhydride;PROPIONIC
ANHYDRIDE, 99+%;PropionicAnhydrideForSynthesis;Propionic anhydride
97%;PROPIONSAEUREANHYDRID |
DESCRIPTION AND APPLICATIONS
Propionic anhydride is a clear liquid with an unpleasant odour. It
hydrates with water producing corrosive propionic acid. It is miscible
in most organic solvents and decomposes with alcohol. Propionic
anhydride used as an intermediate to produce dyes, pharmaceuticals,
agrochemicals and other organic compounds.
SPECIFICATION
 APPEARANCE
: clear liquid
CONTENT : 98.0% min
PROPIONIC ACID : 2.0% max
OTHER INDIVIDUAL IMPURITY : 0.5% max
COLOR : 20 max (Pt/Co scale)
PACKING : 200lgs in drum
HAZARD : CLASS 8 (Packing group : III)
GENERAL DESCRIPTION OF ANHYDRIDE
Anhydride is a compound formed by the abstraction of a molecule of
water, H2O, from a substance. The term acid anhydride is restricted
sometime to the anhydride formed especially from an acid by dehydration
or one that revert to the original substance upon hydration. In case of
bimolecular, it can be composed of two molecules of the corresponding
acid. The term mixed anhydride is an acid anhydride composed of two
different acids. Examples are adenosine triphosphate or an aminoacyl
adenylate. The anhydrides of bases are oxides.
Anhydrides of inorganic acids are usually oxides of nonmetallic
elements. Carbon dioxide (CO2) is the anhydride of carbonic acid,
dinitrogen pentoxide (N2O5) is the anhydride of nitric acid, sodium
oxide is an anhydride of sodium hydroxide, phosphorus pentoxide (P2O5)
is the anhydride of phosphoric acid, and sulfur trioxide (SO3) is the
anhydride of sulfuric acid. An acid anhydride forms an acid; a base
anhydride forms a base. Sulfur trioxide (acid anhydride) reacts with
water to form sulfuric acid (an acid product). Calcium oxide (an base
anhydride) reacts with water to form calcium hydroxide (a base product).
Organic anhydrides contain the carbonyl group (CO). Organic anhydrides
are formed by the condensation of original acids. Lactone, an internal
cyclic monoester, is an anhydride derived from the hydroxyl and carboxyl
radicals. In organic chemistry, most anhydride compounds are derived
from corresponding carboxylic acids. Carboxylic anhydrides, general
formula (RCO)2O, are the dehydration product of two carboxylic acid
molecules. The name of carboxylic anhydride is given first from the
original acid, followed by the separate word "anhydride".
[CH3(CH2)2CO]2O is butanoic anhydride, CH3COOCOCH2CH3 is ethanoic
propanoic anhydride (or acetic propionic anhydride). Anhydrides are more
reactive than the parent acids. Anhydrides are typically not target
molecules, but rather they are used as intermediates for the synthesis
of other organic members such as esters and amides for the industrial
applications include dyes, pharmaceuticals, pesticides, plastics,
fibers, curing agents, plasticizers and many others. The reactivity of
carboxylic acid derivatives are in order of acyl halides > anhydrides >>
esters ¡Ö acids >> amides. Anhydrides react with alcohols to form
esters; acetic anhydride [(CH3CO)2O] reacts with ethanol (C2H5OH) to
form ethyl acetate (CH3COOC2H5) used as a common solvent. Anhydrides
also react with ammonia and primary or secondary amines to form amides.
Anhydrides react with water to form their corresponding acids.
Uses
Propionic anhydride is chiefly used as a raw material for cellulose
acetate propionate, a plaxtic found in face shields, sunglasses, brush
handles, toys, cosmetics containers and blister packages. Propionic
anhydride is also a raw material for dyes, pharmaceuticals,
agrochemicals and fragrance chemicals
Propionic anhydride is an organic compound with the formula
(CH3CH2CO)2O. This simple acid anhydride is a colourless liquid.. It is
a widely used reagent in organic synthesis.
Synthesis
Propionic anhydride has been prepared by dehydration of propionic acid
using ketene
Safety
Propanoic anhydride is strong smelling and corrosive, and will cause
burns on contact with skin. Vapour can burn eyes and lungs.
STORAGE
Separated from acids, bases, oxidants, food and feedstuffs. Dry.
Ventilation along the floor.
 Note:
These API/ chemicals are designated as
those that are used in the manufacture of the controlled substances and
are important to the manufacture of the substances. For any (Control
Substance) products Import and Export *** subjected to your country
government laws /control substance ACT.
Note /Government Notification:
N/A
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India
