DRUG DESCRIPTION
Oxymorphone CAS number
76-41-5
Oxymorphone is in a group of drugs called narcotic pain relievers.
It is similar to morphine.
Oxymorphone is used to treat moderate to severe pain. The
extended-release form of this medication is for around-the-clock
treatment of pain.
Oxymorphone is not for treating pain just after surgery unless you
were already taking oxymorphone before the surgery.
Oxymorphoneis a powerful semi-synthetic opioid analgesic It is
related to morphine in the same fashion that oxycodone is to
codeine, is derived from thebaine, and is approximately 6–8 times
more potent than morphine. It differs from morphine in its effects
all other things being equal in that it generates more euphoria, but
less itching and other histamine effects. Depending on the
individual patient, it can be either more or less nausea- and
vomit-inducing than morphine.
Chemically, oxymorphone is 4, 5α -epoxy-3,
14-dihydroxy-17-methylmorphinan-6-one , a white or slightly
off-white, odorless powder, which is sparingly soluble in alcohol
and ether, but freely soluble in water. The molecular weight of
oxymorphone is 337.80. The pKa1 and pKa2 of oxymorphone at 37°C are
8.17 and 9.54, respectively. The octanol/aqueous partition
coefficient at 37°C and pH 7.4 is 0.98.
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