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Para Anisyl Bromide
CAS Registry Number: 104-92-7
IUPAC Name: 1-bromo-4-methoxybenzene
Synonyms: p-Bromoanisole, Anisyl bromide, p-Bromanisole, Anisole,
p-bromo-, p-Anisyl bromide, 1-Bromo-4-methoxybenzene, 4-BROMOANISOLE,
p-Methoxybromobenzene, 4-Methoxybromobenzene, p-Methoxyphenyl bromide,
4-Methoxyphenyl bromide, Benzene, 1-bromo-4-methoxy-,
4-bromomethoxybenzene, 4-Methoxy-1-bromobenzene, p-Bromophenyl methyl
ether, B56501_ALDRICH, NSC 8042, EINECS 203-252-1, NSC8042, ZINC00404306
Molecular Formula: C7H7BrO
Molecular Weight: 187.033880
PRODUCT IDENTIFICATION
CAS NO 104-92-7
p-BROMOANISOLE
EINECS NO. 203-252-1
FORMULA BrC6H4OCH3
MOL WT. 187.04
H.S. CODEDERIVATION
TOXICITY
Oral, mouse LD50: 2200 mg/kg
SYNONYMS
4-Bromoanisole; 4-Bromo-1-methoxybenzene;
p-Anisyl bromide; 1-Bromo-4-methoxybenzene; p-Bromophenyl methyl ether;
p-Methoxybromobenzene;
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE
clear to slightly yellow liquid
MELTING POINT 9 - 11 C
BOILING POINT 223 C
SPECIFIC GRAVITY 1.494
SOLUBILITY IN WATER immiscible
pH
VAPOR DENSITY 4.28
AUTOIGNITION NFPA RARING
Health: 1; Flammability: 0; Reactivity: 0
REFRACTIVE INDEX 1.563
FLASH POINT 94 C
APPLICATIONS
Ether is any of a number of organic compounds characterized by an oxygen
atom joined with single bonds by two carbon atoms that are part of
hydrocarbon groups. The general formula is R-O-R', where R and R' are
alkyl or aromatic groups. Ethers are formed by the condensation of two
alcohols by heating with sulfuric acid; the reaction is one of
dehydration. Ethers can be prepared from alkyl halide reacted with
metallic alkoxide (called Williamson synthesis). Ethers are similar to
alcohols but are generally less dense, less soluble in water, and have
lower boiling points. They are relatively unreactive, which makes them
valuable solvents. But ethers will be cleaved at high temperatures by
concentrated hydrogen halides. Ethers have relatively low boiling point
compare to alkanes as they don't form hydrogen bonds each other.
Ethers are more lipophilic than esters [R-C(=O)-O-R']or amides
[RCO-NH2]. Ethers are widely used as solvents for various organic
reactions because they are relatively the least reactive among common
organic compounds except alkanes and fluorocarbons. The common reaction
of ethers is cleavage of the C–O bond by strong acids either in linear
chain or cyclic structure. Ethers in which oxygen is bonded to primary
and secondary alkyl groups can form peroxide compounds in the presence
of gaseous oxygen due to two unpaired electrons in oxygen. Ethers can
act as Lewis bases in chemical reactions. Commonly, ethers are named
simply in listing the alkyl groups in alphabetical order or alkane order
such as ethyl methyl ether or methyl ethyl ether, which is methoxyethane
in IUPAC nomenclature ( the formula of "alkoxyalkane" ).
When ether is a parts of complex molecule or aromatic derivatives, it is
described as an alkoxy substituent such as methoxybenzene ( trivial name
is anisole). The methoxy prefix indicates the function methyl group
joined by single bonds to an oxygen atom, with the general formula
-O-CH3. Cyclic ethers have ring structure where the oxygen has become
part of the ring. The term of epoxide indicate three membered cyclic
ether (also called oxirane) in which an oxygen atom is joined to each of
two carbon atoms that are already bonded to each other; four membered
cyclic ether is called oxetane; five membered cyclic ether, furan (or
oxolane); six membered cyclic ether, pyran (also called oxane)
respectively. Their unhindered oxygen atom carries two unshared pairs of
electrons - a structure which favors the formation of coordination
complexes and the solvation of cations. Cyclic ethers are used as
important solvents, as chemical intermediate and as monomer for
ring-opening polymerization. Crown Ether is a macrocyclic polyether
whose structure contains hydrogen, carbon and oxygen atoms. Each oxygen
atoms are confined between two carbon atoms and exhibits a conformation
with a hole (accordingly called "crown"). Anisole is one of the simplest
aromatic compound to which ether group is linked. But it is different
with aromatic compounds like furan where the oxygen is a part of the
ring.
Anisole, C6H5OCH3 (methyl phenyl ether), is a clear liquid that is
soluble in ether and alcohol; insoluble in water; boiling point 155 C.
Anisole and its derivatives are used as solvents and in perfumery.
Anisole can be obtained from anise seed. Anisic acid, p-methoxybenzoic
acid, is a part of cresol class antiseptic compounds. It is also used as
an insect repellent and ovicide. Anisole, anisic acid, and their
derivatives are also widely used in chemical reaction as intermediates
to obtain target materials such as dyes, pharmaceuticals, perfumes,
photoinitiators and agrochemicals.
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Note /Government
Notification: These chemicals are designated as those that are used
in the manufacture of the controlled substances and are important to
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