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Methyl isobutyl ketone
CAS number 108-10-1
 Identifiers
Synonyms: 4-methyl-2-pentanone, 4-methylpentan-2-one,
2-methyl-4-pentanone, 2-methylpropyl methyl ketone,
4-methyl-2-oxopentane, hexone, isopropylacetone, MIK, isobutylmethyl
ketone, MIBK, isohexanone
Use: artificial flavouring
Molecular formula: CH3COCH2CH(CH3)2
CAS No:108-10-1
Molecular Weight: 100.16
Physical data
Appearance: colourless liquid with a pleasant odour
Melting point: -85 C
Boiling point: 116 C
Vapour density: 3.5 (air = 1)
Vapour pressure: 15 mm Hg at 20 C
Density (g cm-3): 0.79
Flash point: 16 C (closed cup)
Explosion limits: 1.1 - 7.5 %
Autoignition temperature:
Water solubility:
Stability Stable. Flammable - note low flash point. Incompatible with
strong oxidizing agents.
Toxicology
Harmful if inhaled. Eye, skin and respiratory irritant. Long-term or
repeated skin contact may cause dermatitis. Chronic high-level exposure
may lead to liver damage. Typical TLV/TWA 50 ppm. Typical STEL 75 ppm.
Toxicity data
(The meaning of any toxicological abbreviations which appear in this
section is given here.)
ORL-RAT LD50 2080 mg kg-1
IHL-MUS LC50 23000 mg m-3
IPR-MUS LD50 268 mg kg-1
Risk phrases
R11 R20.
Personal protection
Safety glasses, adequate ventilation.
Description:
Methyl isobutyl ketone (C.A.S. 108-10-1) is a colorless liquid that is
used as a solvent for vinyl, epoxy, acrylic and natural resins,
nitrocellulose, paints, varnishes, lacquers, protective coatings, rare
metal extraction, and dyes.
It is used as a denaturant for rubbing alcohol, a synthetic flavoring
adjuvant, and a fruit flavoring.
It is used in extracting uranium from fission products, dewaxing mineral
oils, manufacturing antibiotics, dry-cleaning preparations, and the
synthesis of methyl isobutyl carbinol. It occurs naturally in oranges,
grapes, and vinegar.
Chemical properties:
Methyl isobutyl ketone has a faint ketonic and camphor odor. It is
classified under the Clean Air Act as a volatile organic compound. It is
moderately soluble in water, and soluble in alcohol, ether, acetone,
benzene, and chloroform.
It is miscible with most organic solvents. It is reactive or
incompatible with strong oxidizers, potassium, and tert-butoxide. It is
highly flammable and will be easily ignited by heat, sparks, or flame.
Its vapors may form explosive mixtures with air and may travel to the
source of ignition and flash back.
The vapor may explode if ignited in an enclosed area. Most of its vapors
are heavier than air, and its liquids are lighter than water.
Methyl isobutyl ketone ignites on contact with potassium-t-butoxide. It
can react vigorously with reducing materials. Synonyms for methyl
isobutyl ketone include hexone, isobutyl methyl ketone,
4-methyl-2-pentanone, and isopropyl acetone.
Health effects:
Exposure to methyl isobutyl ketone may cause gastrointestinal
disturbances and central nervous system impairment, headache, nausea,
vomiting, and respiratory tract irritation.
Chronic exposure may cause axonal neuropathy, paresthesia, and muscle
weakness.
Ingestion of methyl isobutyl ketone may cause central nervous system
depression, respiratory depression, dyspnea, pulmonary aspiration, and
corrosive effects. Inhalation may cause coma, nausea, headache, vertigo,
incoordination, central nervous system depression, narcosis, dizziness,
tremors, cardiorespiratory failure, and eye, nose, and throat
irritation.
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Note /Government
Notification: These chemicals are designated as those that are used
in the manufacture of the controlled substances and are important to
the manufacture of the substances. For any (Control Substance)
products Import and Export *** subjected to your country government
laws /control substance ACT.
Information: The information on this web page is provided to help
you to work safely, but it is intended to be an overview of hazards,
not a replacement for a full Material Safety Data Sheet (MSDS). MSDS
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The Controlled Substances Act (CSA) was enacted into law by the
Congress of the United States as Title II of the Comprehensive Drug
Abuse Prevention and Control Act of 1970.[1] The CSA is the federal
U.S. drug policy under which the manufacture, importation,
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The Act also served as the national implementing legislation for the
Single Convention on Narcotic Drugs |
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