Cefuroxime Sodium
CAS NO. 56238-63-2
FORMULA C16H15N4O8S
MOL WT. 446.38
H.S. CODE 2941.90
CLASSIFICATION : ANTIBOITICS / CEPHALOSPORINS
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE White to slightly yellowish powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
STABILITY Stable under ordinary conditions.
APPLICATIONS
Cephalosporin: any of a group of broad-spectrum derived from species of
fungi of the genus Cephalosporium and are related to the penicillins in
both structure and mode of action but relatively penicillinase-resistant
antibiotics. These antibiotics have low toxicity for the host,
considering their broad antibacterial spectrum.
They have the active nucleus of beta-lactam ring which results in a
variety of antibacterial and pharmacologic characteristics when modified
mainly by substitution at 3 and 7 positions. Their antibacterial
activities result from the inhibition of mucopeptide synthesis in the
cell wall. They are widely used to treat gonorrhea, meningitis,
pneumococcal, staphylococcal and streptococcal infections. The
cephalosporin class of antibiotics is usually divided into generations
by their antimicrobial properties. Three generations of cephalosporins
are recognized and the fourth has been grouped.
Each newer generation of cephalosporins has broader range of activity
against gram-negative organisms but a narrower range of activity against
gram-positive organisms than the preceding generation. The newer agents
have much longer half-lives resulting in the decrease of dosing
frequency. Accordingly, the third-generation cephalosporins can
penetrate into tissues well, and thus antibiotic levels are good in
various body fluids. Second-generation cephalosporins have broader
spectrums of activity against gram negative coverage but less active
against gram-positive organisms than first-generation agents.
Cefuroxime eliminates bacteria that cause many kinds of infections,
including lung, skin, bone, joint, stomach, blood, and urinary tract
infections. This medication is sometimes prescribed for other uses; ask
your doctor or pharmacist for more information.
Side effects
Cefuroxime may cause side effects. If you are administering cefuroxime
into a muscle, it may be mixed with lidocaine to reduce pain at the
injection site. Tell your health care provider if any of these symptoms
are severe or do not go away:
* diarrhea
* stomach pain
* upset stomach
* vomiting
If you experience any of the following symptoms, call your health care
provider immediately:
* unusual bleeding or bruising
* difficulty breathing
* itching
* rash
* hives
* sore mouth or throat
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