Glibornuride
CAS No. 26944-48-9
Molecular Formula: C18H26N2O4S
Formula Weight: 366.47504
Mechanism of Action
Glibornuride acts by stimulating insulin secretion and is effective only
when some residual pancreatic β-cell activity is present.
Drug Interactions
Diminished hypoglycaemic effect with adrenaline, aminoglutethimide,
chlorpromazine, corticosteroids, diazoxide, oral contraceptives,
rifamycins and thiazide diuretics. Increased hypoglycaemic effect with
ACE inhibitors, alcohol, allopurinol, some analgesics, azole antifungals,
chloramphenicol, cimetidine, clofibrate and related compounds, coumarin
anticoagulants, halofenate, heparin, MAOIs, octreotide, ranitidine,
sulfinpyrazone, sulfonamides, tetracyclines, tricyclic antidepressants
and thyroid hormones. β-blockers increase hypoglycaemia and mask typical
sympathetic warning signs.
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