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NARLOX® Naloxone is a drug used to counter the effects of
overdosing with opioids such as heroin and morphine.
Specifically, naloxone is used in opioid overdoses for
countering life-threatening depression of the central nervous
system and respiratory system. The drug is derived from baine
and has an extremely high affinity for µ-opioid receptors in the
central nervous system.
NARLOX® Naloxone is a µ-opioid receptor competitive antagonist
and the rapid blockade of these receptors often produce rapid
onset of withdrawal symptoms. NARLOX® Naloxone is injected
usually through intravenous route for fastest action. The
drug acts after about two minutes and its effects may last
approximately 45 minutes. Naloxone has been shown to reduce
rates of fatal overdose with heroin.
NARLOX (Naloxone Hydrochloride)
Injection, USP (1 mg/mL)
FOR I.V / I.M USE ONLY
Naloxone is a an opioid antagonist drug. used to counter
the effects of opiate overdose, for example heroin or morphine
overdose. Naloxone is specifically used to counteract
life-threatening depression of the central nervous system and
respiratory system. Naloxone is also experimentally used in the
treatment for congenital insensitivity to pain with anhidrosis
(CIPA), an extremely rare disorder (1 in 125 million)
that renders one unable to feel pain.
NARLOX® Naloxone has an extremely high affinity for μ-opioid
receptors in the central nervous system. Naloxone is a μ-opioid
receptor competitive antagonist, and its rapid blockade of those
receptors often produces rapid onset of withdrawal symptoms.
Naloxone also has an antagonist action, though with a lower
affinity, at κ- and δ-opioid receptors.
NARLOX® Naloxone is most commonly injected intravenously for
fastest action. The drug generally acts within a minute, and its
effects may last up to 45 minutes. It can also be administered
via intramuscular or subcutaneous injection. Use of a wedge
device (nasal atomizer) attached to a syringe to create a mist
delivering the drug to the nasal mucosa [2] - may also be
utilized, although this solution is more likely utilized outside
of a clinical facility.
Counteracting opiate overdose and addiction What is NARLOX™ (naloxone)?
NARLOX™ (naloxone) is an opiate antidote. Opioids include
heroin and prescription pain pills like morphine, codeine,
oxycodone, methadone and Vicodin. When a person is overdosing on
an opioid, breathing can slow down or stop and it can very hard
to wake them from this state. NARLOX™ (naloxone) is a
prescription medicine that blocks the effects of opioids and
reverses an overdose. It cannot be used to get a person high. If
given to a person who has not taken opioids, it will not have
any effect on him or her, since there is no opioid overdose to
reverse. For additional medical information about how naloxone
works click here. There are also many naloxone training and
informational videos available, click here to browse our
resources.
How does NARLOX™ (naloxone) work?
If a person has taken opioids and is then given NARLOX™ (naloxone),
the opioids will be knocked out of the opiate receptors in the
brain. NARLOX™ (naloxone) can help even if opioids are taken
with alcohol or other drugs. After a dose of NARLOX™ (naloxone),
the person should begin to breathe more normally and it will
become easier to wake them. It is very important to give help to
an overdosing person right away. Brain damage can occur within
only a few minutes of an opioid overdose as the result of a lack
of oxygen to the brain. NARLOX™ (naloxone) gives concerned
helpers a window of opportunity to save a life by providing
extra time to call 911 and carry out rescue breathing and first
aid until emergency medical help arrives.
How is NARLOX™ (naloxone) given to an overdosing person?
NARLOX™ (naloxone) can be given by intramuscular (IM) injection
- into the muscle of the arm, thigh or buttocks - or with a
nasal spray device (into the nose). In Illinois, NARLOX™ (naloxone)
is prescribed for use as an IM injection. Nasal spray use is
less common, but some large cities in the U.S. use the nasal
spray version and it can be prescribed.
How long does NARLOX™ (naloxone) take to work?
NARLOX™ (naloxone) generally works within about 5 minutes.
Repeated doses may be necessary if a person is still showing
signs of overdose even after the first dose. Learn how to use
naloxone here.
How long does NARLOX™ (naloxone) take to wear off?
NARLOX™ (naloxone) starts to wear off after about 30 minutes and
is mostly gone after about 90 minutes. By this time the body has
processed enough of the opioids that the overdosing person is
unlikely to stop breathing again. In some cases, such as after
taking a massive dose or using long-acting opioids like
methadone, the patient might need another NARLOX™ (naloxone)
dose and longer medical observation. Always watch the person
after they receive a NARLOX™ (naloxone) dose for signs of
continued overdose.
Who can be prescribed NARLOX™?
According to the Overdose Prevention Act, trained individuals
are allowed to possess and administer NARLOX™ (naloxone) to a
person having an overdose. Physicians may also train individuals
who can then go on to train other individuals (this is called
“train the trainer” model). For more information on how to
prevent, recognize and help in an overdose situation see
harmreduction.org and odprevention.org. Or visit our resources
page for more information.
Where can I get NARLOX™ (naloxone)?
Currently, the main NARLOX™ (naloxone) provider in Illinois is
the Chicago Recovery Alliance. But there are a growing number of
programs and physicians available throughout the state and more
laypeople are being trained in naloxone use all the time. You
can also use the naloxone locator here to find resources near
you. Make sure that you scroll down to see the results. If there
is not a program or a doctor in your area and you are
interesting in getting trained, click here to send us an email.
NARLOX® Naloxone has been distributed as part of emergency kits
to heroin users, and this has been shown to reduce rates of
fatal overdose. Projects of this type are under way in San
Francisco, New Mexico, Philadelphia, New York State, Baltimore,
Boston, Los Angeles, Milwaukee, and Chicago, with pilot projects
started in Scotland in 2006. The combination oxycodone/naloxone
is used for the treatment of opioid-induced constipation under
the trade name Targin and in the Netherlands under Targinact.
Legal status : The patent for NARLOX® Naloxone has
expired and the drug is currently available in various generic
forms.
The CAS number of NARLOX® naloxone is 465-65-6; the anhydrous
hydrochloride salt has CAS 357-08-4.
PACKING AVAILABLE: 1ML, 2ML AMPOULES.
PRODUCT GRADE: USP
SHELF LIFE: 3 YEARS.
MANUFACTURED & EXPORTED
BY: TAJ PHARMACEUTICALS LIMITED (INDIA).
An opiate antidote.to save
life A quality product to save. Humankind
Presentation
NARLOX®
Injection of 1/10ml
Note :This product information is intended only
for residents of the India. Taj Pharmaceuticals Limited,
medicines help to treat and prevent a range of conditions—from the
most common to the most challenging—for people around the world.
Information for Health Care Professionals
*** Please consult local Prescribing
Information for any product before use. This website is an
international information resource for healthcare professionals
with an interest in disease management. This website is not
intended to replace the advice of a qualified healthcare
professional. Above brand is a trademark of the Taj group of
companies (Taj Pharmaceuticals Limited).
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