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COMPOSITION :
GLUCORIDE-GL 501
Each tablet contains
Glimepiride
..
..1 mg
Metformin Hydrochloride extended-release
....500 mg
GLUCORIDE-GL502
Each tablet contains
Glimepiride
..
.2 mg
Metformin Hydrochloride extended-release
...500 mg
INDICATIONS
:
Glucoride-GL is indicated as an adjunct to diet and
exercise to improve glycaemic control in patients with type 2
diabetes who are already treated with a combination of
glimepiride and metformin or whose diabetes is not adequately
controlled with metformin alone, or for those patients who
have initially responded to glimepiride alone and require
additional glycaemic control.
DOSAGE
AND ADMINISTRATION :
General
Dosage should be individualized on the basis of both
effectiveness and tolerance. The combination should be given
once daily with meals and should be started at a low dose. The
initial recommended dose is one tablet once daily with
breakfast or first main meal of the day.
Starting dose for patients inadequately controlled on
metformin monotherapy
Based on the usual starting dose of glimepiride (1-2 mg
daily), Glucoride Gl 501 or Glucoride Gl 502 may be initiated
once daily, and gradually titrated after assessing adequacy of
therapeutic response.
Starting dose for patients who initially responded to
glimepiride monotherapy and require additional glycaemic
control
Based on the usual starting doses of metformin extended
release (500 mg once daily), Glucoride Gl 501 or Glucoride Gl
502 may be initiated once daily, and gradually titrated after
assessing adequacy of therapeutic response .
CONTRAINDICATIONS :
Renal disease or renal dysfunction (e.g., as suggested by
serum creatinine levels ณ 1.5 mg/dL [males], ณ 1.4 mg/dL
[females] or abnormal creatinine clearance), which may also
result from conditions such as cardiovascular collapse
(shock), acute myocardial infarction, and septicaemia.
Congestive heart failure requiring pharmacologic treatment.
Known hypersensitivity to this product or any of its
components.
Acute or chronic metabolic acidosis, including diabetic
ketoacidosis, with or without coma. Diabetic ketoacidosis
should be treated with insulin.
Patients undergoing radiologic studies involving intravascular
administration of iodinated contrast materials, because use of
such products may result in acute alteration of renal function
PACKAGING INFORMATION :
Glucoride-GL
501
...............................Strip of 10 tablets
Glucoride-GL
502
...............................Strip of 10 tablets
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Quality
