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Each tablet contains
Composition
Erythromycin............................................................….250
mg
Erythromycin........................................................…….500
mg
Indications
Acute bacterial pharyngitis, tonsillitis, sinusitis, otitis,
mastoiditis, epiglottitis, bronchitis, pneumonia, erysipelas,
whooping cough, cellulitis, carbuncle, pyoderma, diphtheria,
Legionnaire’s disease, urogenital.
Description
Erythromycin prevents bacteriafrom growing by interfering with
their protein synthesis. Erythromycin binds to the 23s rRNA
molecule in the 50S of the bacterial ribosome, blocking the exit
of the growing peptide chain thus inhibiting the translocation of
peptides.
Side-effects
Gastrointestinal disturbances such as diarrhea, nausea, abdominal
pain and vomiting are fairly common so it tends not to be
prescribed as a first-line drug. However, erythromycin may be
useful in treating gastroparesis due to this pro-motility effect.
Intravenous erythromycin may also be used in endoscopy as an
adjunct to clear gastric contents.
More serious side-effects, such as reversible deafness are rare.
Allergic reactions, while uncommon, may occur, ranging from
urticaria to anaphylaxis. Cholestasis, Stevens-Johnson syndrome
and toxic epidermal necrolysis are some other rare side effects
that may occur.
Erythromycin has been shown to increase the probability of pyloric
stenosis in children whose mothers took the drug during the late
stages of pregnancy or while nursing.
Contraindications
Earlier case reports on sudden death prompted a study on a large
cohort that confirmed a link between erythromycin, ventricular
tachycardia and sudden cardiac death in patients also taking drugs
that prolong the metabolism of erythromycin (like verapamil or
diltiazem) by interfering with CYP3A4 (Ray et al 2004). Hence,
erythromycin should not be administered in patients using these
drugs, or drugs that also prolong the QT time. Other examples
include terfenadine (Seldane, Seldane-D), astemizole (Hismanal),
cisapride (Propulsid, withdrawn in many countries for prolonging
the QT time) and pimozide (Orap).
Dosage
As per the physician’s advice.
Presentations
10 tablets
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Quality
