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Treatment with Alendronate


Alendronate comes as a tablet and a solution (liquid) to take by mouth. The solution is usually taken on an empty stomach once a week in the morning. The 5-mg and 10-mg tablets are usually taken on an empty stomach once a day in the morning, and the 30-mg and 70-mg tablets are usually taken on an empty stomach once a week in the morning. The 40-mg tablets are usually taken once a day in the morning for six months to treat Paget's disease of bone. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take alendronate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Alendronate may not work properly and may damage the esophagus (tube between the mouth and stomach) or cause sores in the mouth if it is not taken according to the recommended instructions.

Alendronate has also been tried for treatment of anorexics, who often have skeletal problems due to malnutrition. However, tests have not been good and alendronate is not widely used for anorexics.

A report in the Journal of Clinical Oncology in 2008 stated that alendronate improves bone density in men having androgen-deprivation therapy for prostate cancer. This was found through the results of a double-blind study. The study authors recommend doctors consider once-a-week alendronate for such patients.

A large study published in 2006 suggested that some women may be able to quit taking alendronate after 5 years without increasing bone fracture risk for another 5 years, but this mode of treatment is not widely used. Some doctors feel the medicine should be stopped because of diminishing returns and because of the possibility (not definitively proven) that the medicine actually causes too much suppression of bone turnover, resulting in bones that become brittle along with increase density.

Recent systematic reviews have continued to show that alendronate reduces the risk of bone fractures. These studies followed women who took the drug for up to four years.

Interestingly, many doctors recommend against monitoring bone marrow density in patients on bisphosphonates, at least during the first three years. The results are thought to be of little value in determining whether to continue bisphosphonate administration. The density often continues to decline after the drug is started (even if the drug is working) and the accuracy of the density tests is not good enough.


Kids don't take this drug (their bones are still growing) and pregnant women don't take it. Alendronate has side effects, but overall it is well tolerated.


Alendronate is not metabolized by the body and stays in the bones for years. While it might not be absorbed in the intestine and eliminate through the feces, alendronate that does enter the bloodstream has a half-life in the body of over 10 years. It is not easily flushed out.

Note : This product information is intended only for residents of the India. Taj Pharmaceuticals Limited,  medicines help to treat and prevent a range of conditions—from the most common to the most challenging—for people around the world.

Information for Health Care Professionals

*** Please consult local Prescribing Information for any product before use. This website is an international information resource for healthcare professionals with an interest in disease management. This website is not intended to replace the advice of a qualified healthcare professional. Above brand is a trademark of the Taj group of companies (Taj Pharmaceuticals Limited).








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