>> Pied piper the switch to turn off cancer?
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‘Pied piper’ the switch
to turn off cancer?
Experts Find Key Cell
Melbourne: Scientists have
discovered a “pied piper” molecule in blood cells, called LIAR,
which they claim can allow growth signals into red blood cells —
and if turned off, might slow certain cancers.
A team in Australia has made the pioneering discovery which
it says could offer a key in treating prostate, breast and colon
cancers as well as leukemia, the findings of which are published
in the journal Blood.
The scientists from Western Australian Institute for Medical
Research, have also identified the function of a known cellular
enzyme, Lyn, as a switch that “turns on” blood cell development.
According to them, the findings are a leap forward in the
understanding of how blood cells develop and divide, which could
offer them a key to turning off cancerous cell growth.
“LIAR is like a key, which opens a pathway into the nucleus
of a blood cell for a number of other molecules, allowing them
to flow in — and these molecules are what signal the cell to
develop and divide.
“From here, if we could control Liar, the hope is that we
could use it to switch off the growth of abnormal, or cancerous,
cells. Because Liar is present in every blood cell, this
knowledge could help treat a huge range of conditions and
diseases, but where it has most potential is in cancers of the
prostate, breast, colon and blood where activity of the enzyme
Lyn is heightened,” team leader Evan Ingley said.
The focus of the team’s investigations, Lyn, has now been
identified as an enzyme which modifies proteins that triggers
the cell to develop further. PTI ‘Daily aspirin in 40s cuts risk of cancer’ People taking an aspirin a day in their forties can cut
the chances of developing cancer later in life, according to
researchers. Those who take the cheap painkiller for 10 years
can reduce the risks of suffering from breast and bowel cancer,
two of the most common forms of the disease. “Taking the drugs
in middle age would maximise the benefits when patients were in
their sixties, when many cancers develop,” Jack Cuzick, of
Cancer Research UK, was quoted by Telegraph as saying. Experts
believe that it works by blocking the effects of proteins in the
body linked to inflammation and found in abundance in some types
of cancer. AGENCIES