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  HOME >> PRODUCTS >> Generic Medicines >>Taj Generics >> Page 1 >> BENZYL PENICILLIN


Active Ingredients:
BENZYL PENICILLIN 600 mg (1 Mu) INTRAMED Powder for Injection
BENZYL PENICILLIN 3,0 g (5 Mu) INTRAMED Powder for Injection



Benzyl penicillin 600 mg per vial, as the sodium salt


Benzyl penicillin 3,0 g per vial, as the sodium salt.
Buffered with 3,0% m/m sodium citrate

       For more information, please see Full Prescribing Information.

A 20.1.2 Penicillins.

Benzyl penicillin 3,0 g per vial, as the sodium salt

The cell walls are essential for normal growth and development of bacteria. Peptidoglycan is the heteropolymeric component of the cell wall providing rigid mechanical stability. The action of the beta-lactam antibiotics is involved in the third stage of cell membrane cross-link formation, namely the transpeptidation reaction. The terminal glycine residue of the pentaglycine bridge is linked to the fourth residue (D-alanine) releasing the fifth residue (also D-alanine) and this step is inhibited by the beta-lactam antibiotics. The transpeptidase is probably acylated by penicillin. Various penicillin binding proteins (transpeptidases and carboxypeptidases) are associated with the bacterial cell membrane and beta-lactam antibiotics bind tightly to them. The penicillin binding proteins vary from one bacterial species to another and in their affinity for different antibiotics. The morphological changes brought about are dependant on the antibiotic, its concentration and the microbe. As the concentration is increased, growth is inhibited, bulges form and lysis follows. Resistant strains (containing no autolysins) will not lysate and different type of antibiotics are to be used.

Bacterial resistance may be because of:


enzymatic structural differences (natural or because of mutation);


inability of antibiotic to permeate its site of action;


enzymatic destruction by beta lactamases or penicillinases.

Its activity is also influenced by:


density of bacterial population and the age of an infection;


these antibiotics are most active against bacteria in the logarithmic phase of growth and have little effect on bacteria in the lagphase;


bacteria that survive inside viable host cells are protected;


low pH or oxygen tension activate the antibiotics.

After intramuscular injection peak plasma concentrations are reached within 15 to 30 minutes. The penicillin G halflife is about 30 minutes. This may be prolonged with Probenecid. Benzyl penicillin is distributed in the body about 50% in the total body water, 90% in the blood is in the plasma and 65% is reversibly bound to plasma albumin. Significant amounts appear in liver, bile, kidney, joint fluid, lymph, intestines and semen. Therapeutically effective concentrations can be attained in the CSF if the meninges are acutely inflamed. It is rapidly excreted by the kidneys.

Benzyl penicillin is highly active against gram-positive cocci and is similar to that of penicillin V in aerobic gram-positive micro-organisms. It is five to ten times more active against gram-negative micro-organisms.

1. Gram-positive Cocci



1st Choice

Dose Mu (Mega-units)

Duration of Therapy

Staphylococcus aureus

Abscesses, Bacteremia, Endocarditis, Pneumonia.

Penicillin G

Penicillin G

10 to 20 mega-units per day

3 to 5 days


Meningitis, Osteomyelitis, Cellulitis, Other.

Penicillin G resistant

A Penicillinase resistant Penicillin





Methicillin resistant




Streptococcus pyogenes

Pharyngitis, Scarlet fever, Otitis media, Sinusitis, Cellulitis, Erysipelas, Pneumonia, Bacteremia,
Other systemic infections


Penicillin G

10 to 20 Mu per day in 4 to 6 portions or continuous infusion

2 to 4 weeks




Penicillin V

500 mg every 6 hours

10 days

Streptococcus (viridans group)

Endocarditis, Bacteremia.


Penicillin G + Streptomycin or Gentamicin

6 to 10 Mu per day -I.V. & Streptomycin 500 mg I.M. twice daily.

2 weeks





Some prefer Pen. G. alone

4 weeks

Streptococcus agalactia
(B group)



Ampicillin or Penicillin G & Amino-glycoside

150 000 to 250 000 units per kg per day parenterally


Streptococcus faecalis (enterococcus)



Penicillin G & Gentamicin or Streptomycin

20 Mu daily -I.V. & Streptomycin 500 mg I.M. every 12 hours or Gentamycin 1 mg/kg every 8 hours

4 to 6 weeks


Urinary tract infection, Bacteremia


Ampicillin or Penicillin G

10 to 20 Mu I.V.

2 weeks

Streptococcus bovis

Endocarditis, Urinary-tract infection, Bacteremia.


Penicillin G & Streptomycin or Gentamicin

10 to 20 Mu I.V.

2 to 4 weeks

Streptococcus (anaerobic species)

Bacteremia, Endocarditis, * Brain and other abscesses, Sinusitis.


Penicillin G

10 to 20 Mu I.V.
*20 Mu daily & Chloramphenicol 2 - 4 g daily I.V. or metronidazole 2 - 4 g daily I.V.

At least 2 weeks

Streptococcus pneumoniae (pneumococcus)

Pneumonia, Endocarditis, Arthritis Sinusitis, Otitis.


Penicillin G

10 to 20 Mu daily I.V.

At least 2 weeks





If there is bone infection, prolong therapy

To at least 4  weeks




Penicillin G

20 to 40 Mu daily by constant I.V. drip or divided into boluses every 2 - 3 hours

14 days

2. Gram-negative Cocci



1st Choice


Duration of therapy

Neisseria gonorrhoea (gonococcus)

Genital infections

Penicillin sensitive

Ampicillin or Amoxicillin Penicillin G
A tetracycline

Only longacting Pen. G plus Probenecid




Penicillinase producing




Arthritis-dermatitis syndrome


Ampicillin or Amoxicillin Penicillin G

10 Mu daily -I.V

3 days





followed by ampicillin or Amoxicillin given orally

5 - 7 days

Neisseria meningitidis

Meningitis, Bacteremia.


Penicillin G

20-24 Mu daily by constant I.V. drip or divided into boluses given every 2 - 3 hours

14 days


Carrier state






3. Gram-positive Bacilli


1st Choice

Dose Mu (million units)

Duration of therapy

Bacillus anthracis

"Malignant pustule", Pneumonia

Penicillin G

10 to 20 Mu

12 days

Corynebacterium diphtheria

Pharyngitis, Laryngotracheitis, Pneumonia, Other local lesions

Penicillin G (Eliminates the carrier state)

2-3 Mu daily
in divided doses

10-12 days


Carrier State




Corynebacterium aerobic and anaerobic (diphtheroids)

Endocarditis, Infected foreign bodies.

Penicillin G and an Aminoglycoside. Vancomycin

2 to 3 Mu dailyin divided doses

10-12 days

Listeria monocytogenes

Meningitis, Bacteremia

Ampicillin or Penicillin G and an Aminoglycoside

15 to 20 Mu daily parenterally

At least 2 weeks
* not less than 4 weeks

Erysipelothrix rhusiopathiae


Penicillin G

When endocarditis present 2-20 Mu daily

4 to 6 weeks

Clostridium perfrigens and other species

Gas Gangrene

Penicillin G

10-20 Mu daily, parenterally
300 mg every 6 hours in prophylactic

7 days

Clostridium tetani


Penicillin G

To eradicate vegetative bacterial forms


4. Gram-negative Bacilli





Pasturella multocida

Abscesses, Wound infection (animal bites), Bacteremia, Meningitis.

Penicillin G

4-6 Mu daily parenterally

At least 2 weeks

Bacteroids species (oral, pharyngeal)

Oral disease, Sinusitis, Brain abscess, Lung abscess.

Penicillin G Clindamycin



Fusobacterium nucleatum

Ulcerative pharyngitis, Lung abscess, Empyema, Genital infections, Gingivitis

Penicillin G Clindamycin Penicillin V

500 mg every 6 hours

5 days

Streptobacillus moniliformis

Bacteremia, Arthritis, Endocarditis, Abscesses.

Penicillin G

12-15 Mu per day given parenterally

3 to 4 weeks

5. Spirochetes Treponema pallidum

Syphilis, primary, secondary or latent

Penicillin G

20 Mu daily I.V.

14 days




followed by 2,4 Mu benzathine Penicillin weekly.

3 weeks




Infants50 000 units per kg in 2 divided doses per day

at least 10 days

Treponema pertenue


Penicillin G




Weil's disease, Meningitis.

Penicillin G Penicillin V or Tetracycline

Oral Penicillin 500 mg every 6 hrs

5 days

6. Actinomycetes
Actinomyces israelii

Cervicofacial, abdominal, thoracic, and other lesions

Penicillin G

10 to 20 Mu daily - I.V.

6 weeks

Must not be administered to patients who are allergic to penicillins.

May cause death when administered to patients sensitive to penicillins. Do not add to containers of infusions containing dextrose. It may be piggy-backed via the same administration set.

See table under indications. It should be limited to use by intravenous route. It can be given as an infusion over 20 to 30 minutes or by constant drip at close intervals (2 to 4 hours). Do not mix with other drugs as it is incompatible with many. Children should receive 100 000 to 250 000 units/kg per day in 4 to 6 portions. Newborns up to 1 week - 50 000 to 150 000 units/kg/day in 2 to 3 portions. Dilute with WATER FOR INJECTIONS. Use only freshly prepared solutions. Discard unused portion.

600 mg (1 Mega-unit) Vial

3 g (5 Mega-unit) Vial


mL solvent


mL solvent

100 000 units/mL

9,6 mL

250 000 units/ mL

17,9 mL

200 000 units/mL

4,6 mL

400 000 units/ mL

10,4 mL

250 000 units/mL

3,6 mL

500 000 units/ mL

7,9 mL

500 000 units/2 mL

3,6 mL

1 000 000 units/ mL

2,9 mL

1 000 000 units/mL

0,6 mL

2 000 000 units/5 mL

10,4 mL

1 000 000 units/5 mL

4,6 mL

5 000 000 units/5 mL

2,9 mL



5 000 000 units/10 mL

7,9 mL

When administered to a hypersensitive patient, anaphylactic shock with collapse and sometimes death may occur within minutes. A generalised sensitivity reaction can occur within 1 to 3 weeks with urticaria, fever, eosinophilia, joint pains, angioneurotic oedema, erythema multiforme and exfoliative dermatitis, although an accelerated urticarial reaction can develop within hours. Glossitis, angular and aphtous stomatitis, and darkening of the tongue are liable to follow the use of penicillin.

Convulsions and other signs of toxicity to the central nervous system may occur with very high doses of benzyl penicillin particularly when administered intravenously to infants, the elderly, to patients with renal failure, or when administered intrathecally in doses above 12 mg.
Nephrotoxicity has occurred in some patients with diminished renal function given large doses of benzyl penicillin. Acute interstitial nephritis, a hypersensitivity reaction, has also been reported. Disturbances of blood electrolytes may follow the administration of large doses of the potassium and sodium salts of benzyl penicillin.

When cutaneous reactions occur, they may subside spontaneously with a few hours or days when penicillin is withdrawn. Control of reactions may be attempted by the administration of antihistamines or, should there be no response with corticosteroids. Desensitisation has been attempted when treatment with penicillin has been considered essential. At the first sign of an immediate reaction to penicillin treatment, 0,3 to 1 mL of Adrenaline Injection should be given intramuscularly (or in severe cases 0,2 mL well diluted intravenously) followed by a further dose if no improvement occurs. This should be followed by an antihistamine, such as diphenhydramine or chlorpheniramine, given parenterally and a corticosteroid given intravenously. If bronchospasm is severe, aminophylline (250 mg in 10 mL) may be given intravenously. Assisted respiration is necessary if there is upper airway obstruction and plasma or suitable electrolyte solutions should be given intravenously if circulatory failure occurs. Urticaria and joint pains, if severe, may be treated with corticosteroids by mouth.

Sterile soluble white powder in a clear glass vial.

Benzyl Penicillin 600 mg (1 Mu) Intramed: In boxes of 100 vials each
Benzyl Penicillin 3 g (5 Mu) Intramed: In boxes of 50 vials each

Benzyl Penicillin 600 mg (1 Mu)  Injection

Store dry, below 25C. KEEP OUT OF REACH OF CHILDREN.
Discard any unused portion.

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Benzyl penicillin Injection

Benzyl penicillin Injection
Benzylpenicillin Injection

BENZYL PENICILLIN 600 mg (1 Mu) INTRAMED Powder for Injection

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