Taj Worldwide | Taj Group | Media | Career | FAQs | Feedback | contact us
 
Taj Logo
diseases_banner
 
Quality Medicines Api Generic Manufacturing For Doctors Brands Newsroom
  Whipple's Disease  
HOME >> Diseases >> Diseases Index >> Index W >> Whipple's Disease
Whipple's Disease  

 

 


What is Whipple’s disease?
Whipple’s disease is a rare bacterial infection primarily affecting the small intestine. It can also affect the heart, lungs, brain, joints, and eyes. Left untreated, Whipple’s disease is fatal.

What causes Whipple’s disease?
Bacteria called Tropheryma whipplei (T. whipplei) cause Whipple’s disease. T. whipplei infection can cause internal sores, also called lesions, and the thickening of tissues. Villi, which are tiny fingerlike projections that line the small intestine, take on an abnormal, club like appearance. The damaged intestinal lining fails to properly absorb nutrients, causing diarrhea and malnutrition.

Scientists are unsure how T. whipplei infects people. One theory is that some people are more vulnerable to Whipple’s disease—probably due to genetic factors that influence the body’s immune system. This theory is supported by the existence of a relatively high number of asymptomatic carriers—people who have the bacteria in their bodies but don’t get sick. Also, the bacteria are more common in the environment—showing up in soil and sewage wastewater—than would be predicted based on the rareness of the disease. And while multiple cases of Whipple’s disease have occurred within the same family, no documentation exists of a person-to-person transmission.

Who gets Whipple’s disease?
Anyone can get Whipple’s disease, but it is more common in middle-aged Caucasian men.

What are the signs and symptoms of Whipple’s disease?
Signs and symptoms of Whipple’s disease vary widely.

Classic signs and symptoms of Whipple’s disease include

periodic joint pain, with or without inflammation, that may persist for years before the appearance of other symptoms
chronic diarrhea, with or without blood
weight loss
abdominal pain and bloating
fever
fatigue
anemia—a condition in which the blood has a lower-than-normal number of red blood cells

Less common signs and symptoms of Whipple’s disease include

darkening of the skin
enlarged lymph nodes
chronic cough
chest pain
pericarditis—inflammation of the membrane surrounding the heart
heart failure

Neuralgic symptoms occur in some people diagnosed with Whipple’s disease and can mimic symptoms of almost any other neuralgic condition.

Neurological symptoms of Whipple’s disease include

vision problems
dementia
facial numbness
headache
muscle weakness or twitching
difficulty walking
memory problems

Symptoms of neuralgic, lung, or heart disease occasionally appear without gastrointestinal symptoms.

How is Whipple’s disease treated?
Whipple’s disease is treated with long-term antibiotics that kill T. whipplei bacteria.

Standard therapy for Whipple’s disease involves initial treatment with intravenous (IV) antibiotics for 2 weeks, followed by daily oral antibiotic treatment for 1 to 2 years. IV antibiotics are delivered through a needle inserted into a vein. IV antibiotics used to treat Whipple’s disease include ceftriaxone (Rocephin) and penicillin G (Pfizer pen) plus streptomycin. Trimethoprim/sulfamethoxazole (Septra, Bactrim), a combination oral antibiotic that can enter the cerebrospinal fluid and brain, is commonly used to treat Whipple’s disease.

An alternative treatment for Whipple’s disease is a combination of doxycycline (Vibramycin) plus the ant malarial drug hydroxychloroquine (Plaquenil) taken for 12 to 18 months. Supporters of this approach recommend that people with neurologic Whipple’s disease also take long-term antibiotics that can enter the cerebrospinal fluid and brain, such as sulfamethoxazole.
 


  Growing Stronger, Growing
  Better
medicine
 
  Global Health
 
world
 
  Healthcare Provider
 
company_pharma

 

 

 

 

 

 

 

 

 

 




 

 

 

 

 

 

 

 

 

 

 
Whipple’s - treatment of Whipple’s, Whipple’s types, Disease medicines, Whipple’s symptoms, Whipple’s and Disease symptoms, Whipple’s symptoms Disease and diagnosis, Symptoms and Solutions, Signs and Symptoms, type of Whipple’s, cause common, common Whipple’s, Whipple’s List, causes list, Infectious Whipple’s, Causes, Diseases , Types, Prevention, Treatment and Facts, Whipple’s information, Whipple’s: Definition, Whipple’s names, medical Whipple’s, medical Whipple’s and disorders, cell Whipple’s, Whipple’s Worldwide, Whipple’s Research, Whipple’s Control, Whipple’s Center, Digestive Whipple’s Week, Information about Whipple’s, causes of different Whipple’s, Whipple’s Articles, Whipple’s and conditions, Health and Whipple’s, Whipple’s Patients, Whipple’s and Sciences, causes of alzheimer's Whipple’s, Whipple’s causes, alternative medicine heart Whipple’s, body ailments, Whipple’s medicines, medical antiques, type of blood Whipple’s  
 
   
diseases
  diseases index
 
   
  india flag
  The Taj Pharmaceuticals Limited (Taj Group) has operations in every major international market
   
  RESEARCH & DEVELOPMENT
  CONSUMER CARE
  MEDICAL CARE
  ANIMAL HEALTH
  TECHNOLOGY
  SOCIAL RESPONSIBILITY
  DRUGS INFORMATION
  FIRST AID & EMERGENCY GUIDE
  DIET & NUTRITION
  AMAZING BODY FACTS
 
YOGA FOR HEALTH
 
 www.tajpharma.com

 

   
 

          
 Print page   Send by mail

   

About Taj

Company

Products Diseases Health Divisions Media R & D Sustainability
Figure & Reports Investors

Countries

Brochure E-mail us Export & Import
Vacancies | C & F Agency | Distributor | Group Companies | History | Enquire Form | Countries | Pharma Technology
 Contact | Sitemap | User Terms and Conditions | Privacy and Cookie Statement