What is pulmonary
hypertension?
The right ventricle pumps blood returning from the body into the
pulmonary arteries to the lungs to receive oxygen. The pressures
in the lung arteries (pulmonary arteries) are normally
significantly lower than the pressures in the systemic
circulation. When pressure in the pulmonary circulation becomes
abnormally elevated, it is referred to as pulmonary hypertension,
pulmonary artery hypertension, or PAH.
Pulmonary hypertension generally results from constriction, or
stiffening, of the pulmonary arteries that supply blood to the
lungs. Consequently, it becomes more difficult for the heart to
pump blood forward through the lungs. This stress on the heart
leads to enlargement of the right heart and eventually fluid can
build up in the liver and other tissues, such as the in the legs.
What
are primary and secondary pulmonary hypertension?
In the conventional classification, pulmonary hypertension, which
is also called pulmonary arterial hypertension, is divided into
two main categories; 1) primary pulmonary hypertension (not caused
by any other disease or condition); and 2) secondary pulmonary
hypertension (caused by another underlying condition). Secondary
pulmonary hypertension is much more common than primary pulmonary
hypertension.
A newer classification of this condition is based on the main
underlying cause of pulmonary hypertension. This system classifies
the condition based on whether it is due to:
left sided heart disease,
lung disease,
blood clots,
constriction of arteries due to any reasons
(including primary pulmonary hypertension), and
obstruction from outside of blood vessel (for
example from diseases of the chest wall compressing the blood
vessels).
What is
the treatment for pulmonary hypertension?
The treatment for pulmonary hypertension depends on the underlying
cause.
If left sided heart failure is the primary problem, then adequate
treatment of the left heart failure by a cardiologist is the main
stray of treatment.
In cases where hypoxia (low oxygen levels) due to any chronic lung
disease, such as COPD, is the cause, then providing oxygen and
appropriately treating the underlying lung disease by a lung
doctor (pulmonologist) is the first step in treatment.
In conditions, such as scleroderma, which often can cause
pulmonary hypertension, a rheumatologist is involved in the
treatment program.
Anticoagulation (thinning the blood) may be a treatment option if
the main underlying cause is thought to be recurrent blood clot
(chronic thromboembolic pulmonary hypertension). As indicated in
previous section, referral to a specialty center may be warranted
for a possible surgical removal of blood clot (thromboendarterectomy).
For patients with primary pulmonary hypertension (those with no
underlying cause), more advanced therapy may be attempted. These
drugs have complex mechanisms, but in general they work by
dilating (opening up) the pulmonary arteries and, therefore, by
reducing the pressure in these blood vessels.
Some of the most commonly used drugs prescribed to treat pulmonary
hypertension include:
epoprostenol (Flolan),
bosentan (Tracleer),
intravenous treprostinil (Remodulin),
inhaled iloprost (Ventavis),
sildenafil (Viagra, Revatio),
calcium channel blockers (such as nifedipine),
sitaxsentan (Thelin) - not FDA approved in
the U.S., and
ambrisentan (Letairis).
These more advanced therapies
can also be used for secondary pulmonary hypertension that may be
too severe and not adequately controlled by the usual treatment of
the underlying condition.
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