Each Tablet contains:
Molsidomin.......................2/4mg
COMPOSITION :
Molsidomine - 2
Each enteric-coated tablet contains
Molsidomin.......................2mg
Molsidomine - 4
Each enteric-coated tablet contains
Molsidomin.......................4mg
Molsidomine, an effective long-acting anti-anginal drug:
Molsidomine is an orally active, long acting, NO releasing
vasodilator which requires hepatic metabolism for activity but
which does not cause pharmacological tolerance. Molsidomine is a
NO-releasing prodrug. Liver esterases convert molsidomine to the
active metabolite, SIN-1 (half-life in plasma is 1-2 hours), which
then releases NO.
Used: in severe cases of angina pectoris.
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Abstract :
Molsidomine was compared with propranolol for anti-anginal
efficacy in a double-blind, cross-over, fixed-dose clinical trial,
involving 39 patients with moderate, stable angina pectoris, and
objective evidence of coronary sclerosis. The incidence of anginal
attacks under molsidomine did not differ statistically from that
under propranolol. However, propranolol was more effective in
reducing the nitroglycerin requirement at the doses used.
Ergometry showed that both drugs increased exercise tolerance to a
comparable extent. However the rate pressure product during
exertion indicates that these drugs achieve this result via
different paths, molsidomine having a nitrate-like effect.
Unwanted effects during the four week treatment periods were minor
and generally tolerable.
Molsidomine is an effective long-acting anti-anginal agent with
nitrate-like effects and should be a useful addition to the drugs
already in use.
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Pharmaceutical active ingredients:
Molsidomine
Forms:
Tablet; Oral; Molsidomine 2 mg
Tablet; Oral; Molsidomine 4 mg
Injectable; Injection; Molsidomine 2 mg / ml
Destination
/ Category:
Human
Indications and usages:
ATC
ICD-10
DOSAGE AND ADMINISTRATION
Prevention of ischaemic events
The recommended dose is one tablet once daily.
Acute coronary syndrome
Loading dose:
Four tablets.
Maintenance:
One tablet daily
PACKAGING INFORMATION :
Molsidomine -2: Blister of 10 tablets
Molsidomine -4: Blister of 10 tablets
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