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Melioidosis |
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What is melioidosis? What causes melioidosis?
Melioidosis, also called Whitmore's Disease, is an infectious
disease caused by a bacterium called Burkholderia pseudomallei
(previously known as Pseudomonas pseudomallei). The bacteria are
found in contaminated water and soil and spread to humans and
animals through direct contact with the contaminated source. The
bacteria are also of some concern as a potential agent for
biological warfare and biological terrorism.
Melioidosis is similar to glanders disease, which is passed to
humans from infected domestic animals.
What are symptoms of melioidosis?
Melioidosis symptoms most commonly stem from lung disease where
the infection can form a cavity of pus (abscess). The effects can
range from mild bronchitis to severe pneumonia. As a result,
patients also may experience fever, headache, loss of appetite,
cough, chest pain, and general muscle soreness.
The effects can also be localized to infection on the skin (cellulitis)
with associated fever and muscle aches. It can spread from the
skin through the blood to become a chronic form of melioidosis
affecting the heart, brain, liver, kidneys, joints, and eyes.
Melioidosis can be spread from person to person as well
How is
melioidosis treated?
The treatment of melioidosis involves antibiotics and depends on
the location of the disease.
For patients with more mild illness, the CDC recommends
antibiotics such as imipenem, penicillin, doxycycline,
amoxicillin-clavulanic acid, ceftazidime, ticarcillin-clavulanic
acid, ceftriaxone, and aztreonam. Patients who are more severely
ill are given a combination of two of the above for up to 12
months.
With pulmonary involvement of melioidosis, if cultures remain
positive for six months, surgical removal of the lung abscess with
lobectomy is consider
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