Legionellosis is an infectious disease caused by Gram negative,
aerobic bacteria belonging to the genus Legionella. Over 90% of
legionellosis cases are caused by Legionella pneumophila, a
ubiquitous aquatic organism that thrives in temperatures between
25 and 45 °C (77 and 113 °F), with an optimum around 35 °C (95
°F).
Legionellosis takes two distinct forms:
Legionnaires' disease, also known as "Legion Fever, is the more
severe form of the infection and produces pneumonia.
Pontiac fever is caused by the same bacterium but produces a
milder respiratory illness without pneumonia that resembles acute
influenza.
Legionnaires' disease acquired its name in July 1976 when an
outbreak of pneumonia occurred among people attending a convention
of the American Legion in Philadelphia. On January 18, 1977 the
causative agent was identified as a previously unknown bacterium,
subsequently named Legionella. Some people can be infected with
the Legionella bacterium and have only mild symptoms or no illness
at all.
Outbreaks of Legionnaires' disease receive significant media
attention. However, this disease usually occurs as single,
isolated cases not associated with any recognized outbreak. When
outbreaks do occur, they are usually in the summer and early
autumn, though cases may occur at any time of year. The fatality
rate of Legionnaires' disease has ranged from 5% to 30% during
various outbreaks. "The death rate for patients who develop
Legionnaire's disease while in the hospital is close to 50%,
especially when antibiotics are started late," according to the
NIH and U.S. National Library of Medicine service's MedlinePlus.
Most infections occur in those who are middle-age or older
Signs and symptoms
Patients with Legionnaires' disease usually have fever, chills,
and a cough, which may be dry or may produce sputum. Some patients
also have muscle aches, headache, tiredness, loss of appetite,
loss of coordination (ataxia), and occasionally diarrhea and
vomiting. Laboratory tests may show that patients’ renal
functions, liver functions and electrolytes are deranged,
including hyponatremia. Chest X-rays often show pneumonia with
bi-basal consolidation. It is difficult to distinguish
Legionnaires' disease from other types of pneumonia by symptoms or
radiologic findings alone; other tests are required for diagnosis.
Persons with Pontiac fever experience fever and muscle aches
without pneumonia. They generally recover in 2 to 5 days without
treatment.
The time between the patient's exposure to the bacterium and the
onset of illness for Legionnaires' disease is 2 to 10 days; for
Pontiac fever, it is shorter, generally a few hours to 2 days.
Cause
L. pneumophila is specifically considered as a pathogen of the
respiratory tract. Other infections have also been reported,
including haemodialysis fistulae, pericarditis, and wound and skin
infections. Bacteraemia is often associated with Legionnaires'
disease. Intestinal infections may only occur as part of
respiratory infections, and where gastrointestinal symptoms have
on occasion been described.
No animal infections have been specifically recorded.
Infections of protozoa such as Hartmannella vermiformis and
related protozoa have been shown to be able to support the growth
of L. pneumophila in tap water. Also Acanthamoeba, Naegleria and
Tetrahymena can be infected by L. pneumophila. pathway may be how
these organisms survive in the environment.
Legionellosis infection normally occurs after inhaling an aerosol
(suspension of fine particles in air) containing Legionella
bacteria. Such particles could originate from any infected water
source. When mechanical action breaks the surface of the water,
small water droplets are formed, which evaporate very quickly. If
these droplets contain bacteria, the bacteria cells remain
suspended in the air, invisible to the naked eye but small enough
to be inhaled into the lungs. This often occurs in poorly
ventilated areas such as prisons where a condensating air
conditioner can spread it throughout the entire room, infecting
anyone not immune to the strand of bacteria. Potential sources of
such contaminated water include cooling towers used in industrial
cooling water systems as well as in large central air conditioning
systems, evaporative coolers, hot water systems, showers,
whirlpool spas, architectural fountains, room-air humidifiers, ice
making machines, misting equipment, and similar disseminators that
draw upon a public water supply. The disease may also be spread in
a hot tub if the filtering system is defective. Freshwater ponds,
creeks, and ornamental fountains are potential sources of
Legionella The disease is particularly associated with hotels,
cruise ships and hospitals with old, poorly maintained pipework
and cooling systems. A study published by the European Journal of
Epidemiology points to automotive windshield washing systems as a
source, recommending the addition of an antibacterial agent to the
system's reservoir.
Various studies have shown that some 40% to 60% of cooling towers
tested contained Legionella.
A recent research study provided evidence that Legionella
pneumophila, the causative agent of Legionnaires' disease, can
travel airborne at least 6 km from its source. It was previously
believed that transmission of the bacterium was restricted to much
shorter distances. A team of French scientists reviewed the
details of an epidemic of Legionnaires' disease that took place in
Pas-de-Calais in northern France in 2003–2004. There were 86
confirmed cases during the outbreak, of whom 18 died. The source
of infection was identified as a cooling tower in a petrochemical
plant, and an analysis of those affected in the outbreak revealed
that some infected people lived as far as 6–7 km from the plant.
A study of Legionnaires' disease cases in May 2005 in Sarpsborg,
Norway concluded that: "The high velocity, large drift, and high
humidity in the air scrubber may have contributed to the wide
spread of Legionella species, probably for >10 km. ...
In 2010 a study by the UK Health Protection Agency reported that
20% of cases may be caused by infected windscreen wiper water. The
finding came after researchers spotted that professional drivers
are five times more likely to be infected.
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