What is Charcot-Marie-Tooth ?
Charcot-Marie-Tooth Disease
refers to a hereditary neurological disorder affecting primarily
the legs, feet and hands. It is also known as Hereditary
Motor-Sensory Neuropathy (HMSN) and Peroneal Muscle Atrophy.
Charcot-Marie-Tooth (CMT) Disease is one of the more common
hereditary diseases. One in 2,500 people is afflicted with some
form of CMT.
CMT is a neurological disorder because it affects the peripheral
nerves that supply the lower body. CMT is divided into two general
types, Type I and Type II. Different forms of CMT fall under these
two types. Type I affects the myelin sheath that surrounds the
nerve fiber. Degeneration of the myelin sheath results in slowed
conduction of the nerve signals to the muscles. Type II affects
the nerve fibers itself. Conduction is generally normal, but
abnormalities are evident in the nerve signals. Because of poor
innervation, the muscles of the lower limbs start to weaken and
waste away and atrophy. Early symptoms of CMT include high arch of
the feet and flexed toes. Some varieties of CMT are associated
with other disorders. These include CMT with Freidrich Ataxia,
with Ptosis, and with Parkinsonism. Onset generally occurs either
in childhood or adolescence. Symptoms vary in severity and
progressively worsen. There is no cure for CMT, however, various
treatments are widely available. They range from physical therapy,
leg braces, shoe inserts and surgery to correct any severe
abnormalities. Affected individuals are more vulnerable to injury.
CMT usually isn’t life-threatening and
almost never affects brain function. It is not contagious, but it
is hereditary and can be passed down from one generation to the
next. CMT...
* ...is also known as peroneal muscular atrophy (PMA) and
hereditary motor sensory neuropathy (HMSN).
* ...is slowly progressive, causing deterioration of peripheral
nerves which control sensory information and muscle function of
the foot/lower leg and hand/forearm.
* ...causes degeneration of peroneal muscles (located on the front
of the leg below the knees).
* ...causes foot-drop walking gait, foot bone abnormalities, high
arches and hammertoes, problems with balance, problems with hand
function, occasional lower leg and forearm muscle cramping, loss
of some normal reflexes, scoliosis (curvature of the spine) and
sometimes, breathing difficulties.
* ...does not affect life expectancy, but can, in rare instances,
cause severe disability.
* ...has no cure, although physical therapy, occupational therapy
and moderate physical activity are beneficial.
* ...is sometimes surgically treated.
* ...is usually inherited in an autosomal dominant pattern, which
means if one parent has CMT there is a 50/50 chance of each child
inheriting the disorder.
* ...may become worse if certain neurotoxic drugs are taken.
* ...can vary greatly in severity, even within the same family.
* ...can now be diagnosed by a blood test (CMT types: 1A, 1B, 1C,
1D, 1E, 1F, 1X, 2A, 2B, 2E, 2F, 2I, 2J, 2K, 4A, 4C, 4E, 4F, 4J,
HNPP, CHN, and DSN).
Global Health
Hereditary peripheral
neuropathy dislocation of toes and plantar sore
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