Acne occurs when the oil glands of the
skin become plugged. It is more common in people with oily skin.
Acne occurs in adolescents and young adults. In acne there are
blackheads (the plugs found in blocked-off oil glands), whiteheads
(pimples), or red bumps on the face, neck, and shoulders.
What is the cause?
Acne is due to over activity and plugging of the oil glands. The
main underlying cause of acne is increased levels of hormones
during adolescence. Acne is not caused by diet. A person who has
acne does not have to avoid eating fried foods, chocolates, or any
other food.
Acne is not caused by sexual activity. It is not caused by dirt
nor by not washing the face often enough. The tops of blackheads
are black because of the chemical reaction of the oil plug with
the air. Acne usually lasts until the age of 20 or sometimes 25.
It is rare for acne to leave any scars, and people worry
needlessly about this.
How to take care of acne?
Good skin care can keep acne under control and at a mild level.
* Wash the skin twice a day using a mild soap, especially after
exercise. Avoid scrubbing the skin. Hard scrubbing of the skin is
harmful because it irritates the openings of the oil glands and
can cause them to be more tightly closed.
* Avoid putting any oily or greasy substances on the face. Oily
and greasy substances make acne worse by blocking oil glands. If
unavoidable, use water-based cover-up cosmetics, and wash them off
at bedtime.
* Shampoo the hair daily. Avoid hair tonics or hair creams
especially greasy ones. These substances spread to the face and
aggravate the acne.
* Avoid picking blackheads as this delays healing. In general, it
is better not to "pop" pimples.
* Exercise regularly and keep fit.
* Don't stop the acne medicine too soon. It may take up to 8 weeks
for a good response.
What are the types of acne?
Acne can be classified into four main types: purely comedonal i.e.
non-inflammatory acne; mild papular; scarring papular and nodular
or scarring acne.
Comedonal acne: It is the non-inflammatory acne, which is the
mildest form of disease but can be the hardest to treat. Comedones
are usually firmly seated in the follicle.
Inflammatory acne: It is the mild papulopustular acne, which
rarely results in scarring and typically is responsive to
aggressive, twice daily, topical treatment.
What is the treatment?
Many doctors seem tempted to use as many as five or six
treatments. Most acne can be treated effectively with two drugs,
or at most three, at any one time. Failure to respond to a regimen
within four to eight weeks should prompt a substantial change in
drugs, not merely the addition of another product.
Tretinoin, isotretinoin, adapalene, and tazarotene are topical
retinoids which, if applied daily, inhibit formation of comedones
and usually clear even severe comedonal acne within a few months.
The only major drawback is irritation, which is greatest after a
few weeks, but the irritation usually requires no more than simple
moisturising. Azelaic acid is a dicarboxylic acid with modest
antibacterial and comedolytic effects. It is the least irritating
preparation. The side effects: in dark skinned patients,
inflammation results in hyperpigmentation, which could otherwise
remain for weeks or months.
Usually, two drugs are prescribed an antibacterial and a
comedolytic. Benzoyl peroxide 2.5-10% is extremely effective
against this type of acnes. Its major disadvantage is irritation,
which can be minimised by using lower concentrations in a cream
vehicle. Topical erythromycin and clindamycin are available as
alcoholic solutions, lotions, creams, and gels, all of which are
about equally effective. A combination of clindamycin and benzoyl
peroxide in gel form is superior to a topical antibiotic alone.
Azelaic acid 20% cream is also an effective alternative. Failure
to respond to topical treatment within four to eight weeks should
automatically prompt a change in treatment. Other options for
resistant P acnes include oral antibiotics and isotretinoin.
Solutions for acne that is resistant to
treatment:
Investigate compliance
Increase frequency of topical treatment
Begin or increase oral antibiotic dosage
Search for hormonal derangement
Begin oral isotretinoin therapy
Oral treatment:
Acne that is resistant to topical treatment requires oral
antibiotics. Many of the antibiotics useful in acne also have an
anti-inflammatory activity, which is nearly as important as their
effect on the P acnes itself. Oral erythromycin used to be a
common treatment for acne, but the rise of resistance has greatly
reduced its utility. It is necessary to begin the treatment with
doxycycline or minocylcine. Acquired resistance to minocycline and
doxycycline is less common than to erythromycin but is still a
concern, and use of these drugs should be limited to those
patients who truly need them. Patients are instructed to take the
drug with food this minimises stomach complaints and maximises
compliance. If minocycline or doxycycline cannot be used,
alternatives include co-trimoxazole and ciprofloxacin. Risk of
acquiring resistance to these drugs after long-term use has not
been studied, but the use of these drugs should be minimised. In
general, cephalosporins and penicillins are not very effective in
treating acne. The increased cost of some of these newer drugs may
make using isotretinoin an attractive option in the long-term
treatment.
Hormonal treatment:
It is wrong to assume that any woman with acne have a hormonal
derangement. In fact, androgen levels do not correlate with acne
severity among people with acne. Acne resistant to treatment,
especially in a woman with irregular menses, should be
investigated. Measurements of total and free testosterone as well
as dehydroepiandrosterone sulphate. If these levels are raised,
four approaches may be taken: suppression with low dose oral
corticosteroid, oral contraception, cyproterone acetate or
spironolactone.
Isotretinoin revolutionised the treatment of severe acne. It is
used in case of severe nodular acne, but it is commonly used for
severe acne that is resistant to oral antibiotics as well.
Patients should be monitored routinely.
Acne and pregnancy:
Erythromycin, topical or oral, is safe in pregnancy, although oral
erythromycin is often poorly tolerated in patients whose lower
oesophageal sphincter is already relaxed by pregnancy. Benzoyl
peroxide is also safe. Topical tretinoin in pregnancy is
theoretically safe as circulating vitamin A. No increase in foetal
abnormalities has been seen in women using topical tretinoin while
pregnant.
Healthcare Skin Provider
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