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Each kit contains
Composition
1 cap of Rifampicin..............................................450
mg
1 Tab of Ethambutol............................................800
mg
1 Tab of INH.......................................................150
mg
2 Tab of Pyrazinamide.........................................750
mg
Indications
Rifampicin, Ethambutol, Isoniazid, Pyrazinamide and Streptomycin
are used in medication and management of Tuberculosis.
Description
Rifampicin inhibits DNA-dependent RNA polymerase in bacterial
cells by binding its beta subunit, thus preventing transcription
of messenger RNA (mRNA) and subsequent translation to proteins.
Ethambutol is a synthetic, bacteriostatic antitubercular agent.
Ethambutol diffuses into actively growing mycobacteria cells such
as tubercle bacilli . It appears to inhibit the synthesis of one
or more metabolites, thus impairing cell metabolism, arresting
multiplication, and resulting in cell death.
INH is thought to work through its effects on lipids (fats) and
DNA within the tuberculosis bacterium.
Pyrazinamide is a prodrug that stops the growth of Mycobacterium
tuberculosis. M. tuberculosis has the enzyme pyrazinamidase which
is only active at acidic pH. Pyrazinamidase converts pyrazinamide
to the active form, pyrazinoic acid. Pyrazinoic acid inhibits the
enzyme fatty acid synthetase I, which is required by the bacterium
to synthesise fatty acids.
Dosage
Adults: (below 50 kg): 450 mg daily as a single dose. More than 50
kg: upto 600 mg daily.
Children: 10-15 mg /kg body wt. daily as single dose.
Presentations
1 kit
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Quality
