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Each hard gelatin capsule contains
Composition
Amoxycillin Trihydrate I.P........................................
........250 mg
(equivalent to Amoxycillin) Cloxacillin Sodium I.P...........250
mg
(Equivalent to cloxacillin) Lactic Acid Bacillus. 80 millino
Spores
Indications
Lower respirator tract, skin and soft tissue,urinary tract and
post-operative infections. Osteomyelitis, gynaecological, serious
infections like septicaemia, bacterial endocarditis, brain abscess
and bacterial meningitis.
Description
Amoxicillin binds to penicillin-binding protein 1A (PBP-1A)
located inside the bacterial cell well. Penicillins acylate the
penicillin-sensitive transpeptidase C-terminal domain by opening
the lactam ring. This inactivation of the enzyme prevents the
formation of a cross-link of two linear peptidoglycan strands,
inhibiting the third and last stage of bacterial cell wall
synthesis. Cell lysis is then mediated by bacterial cell wall
autolytic enzymes such as autolysins; it is possible that
amoxicllin interferes with an autolysin inhibitor.
Contraindication
A history of allergic reaction to any of the penicillins is a
contraindication.
Dosage
Adults : 500 mg-1g of combination thrice daily. Children :
50-100mg/kg body -wt. daily in 3 divided doses.
Presentations
10 tablets
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Quality
