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Each Injection contains
Composition
Pantoprazole
..................................................................40
mg
Indications
Protozole reduces the amount of acid in the stomach and duodenum.
This helps to heal peptic ulcers and helps to prevent them from
recurring. It also helps to relieve the symptoms of
reflux oesophagitis.
Description
Proton pump inhibitors act by irreversibly blocking the
hydrogen/potassium adenosine triphosphatase enzyme system ( the
H+/K+ ATPase, or more commonly just gastric proton pump) of the
gastric parietal cell. The proton pump is the terminal stage n
gastric acid secretion, being directly responsible for secreting H
+ ions into the gastric lumen, making it an ideal target for
inhibiting acid secretion.
Targeting the terminal-step in acid production, as well as the
irreversible nature of the inhibition, result in a class of drugs
t hat is significantly more effective than H2 antagonists and
reduces gastric acid secretion by up to 99%.
The lack of the acid in the stomach will aid in the healing of
duodenal ulcers, and reduces the pain from indigestion and h
eartburn, which can be exacerbated by stomach acid. However,
lack of stomach acid may also contribute to hypochlorhydria, a
lack of sufficient hydrochloric acid, or HCl. Hydrochloric acid is
required for absorption of nutrients, particularly calcium.
The proton pump inhibitors are given in an inactive form. The
inactive form is neutrally charged (lipophilic) and readily
crosses cell membranes into intracellular compartments (like the
parietal
cell canaliculus) that have acidic environments. In an acid
environment, the inactive drug is protonated and rearranges into
its active form. As described above, the active form will
covalently and irreversibly bind to the gastric proton pump,
deactivating it.
Dosage
As per the physician’s advice.
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Quality
