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Each film-coated tablet contains
Composition
Sildenafil
Citrate...............................................................100
mg
Indications
NEOGRA is indicated for the treatment of erectile dysfunction in
men.
Description
Part of the physiological process of erection involves the
parasympathetic nervous system causing the release of nitric oxide
(NO) in the corpus cavernosum of the penis. NO binds to the
receptors of the enzyme guanylate cyclase which results in
increased levels of cyclic guanosine monophosphate (cGMP), leading
to smooth muscle relaxation (vasodilation) in the corpus
cavernosum, resulting in increased inflow of blood and an
erection.
Sildenafil is a potent and selective inhibitor of cGMP specific
phosphodiesterase type 5 (PDE5) which is responsible for
degradation of cGMP in the corpus cavernosum. The molecular
structure of sildenafil is similar to that of cGMP and acts as a
competitive binding agent of PDE5 in the corpus cavernosum,
resulting in more cGMP and better erections. Without sexual
stimulation, and therefore lack of activation of the NO/cGMP
system, sildenafil should not cause an erection. Sildenafil is
metabolised by hepatic enzymes and excreted by both the liver and
kidneys. If taken with a high-fat meal, there may be a delay in
absorption of sildenafil and the peak effect might be reduced
slightly as the plasma concentration will be lowered
Contraindications
Use of NEOGRA is contraindicated in patients with a known
hypersensitivity
to any component of the tablet. Consistent with its known effects
on the
nitric oxide/cGMP pathway, sildenafil was shown to potentiate the
hypotensive effects of nitrates, and its administration to
patients who are
concurrently using organic nitrates in any form is therefore
contraindicated.
Dosage
For most patients, the recommended dose is 50 mg taken, as needed
approximately 1 hour before sexual activity. However, NEOGRA may
be taken anywhere from 4 hours to 0.5 hour before sexual activity.
Based on effectiveness and toleration, the dose may be increased
to a maximum recommended dose of 100 mg or decreased to 25 mg. The
maximum recommended dosing frequency is once per day.
Presentations
4 Tablets
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Quality
