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Each uncoated tablet contains
Composition
Nimesulide B.P...............................................................100
mg
Paracetamol I.P..............................................................325
mg
Excipients............................................................................q.s.
Indications
Painful inflammatory conditions namely osteoarthritis, rheumatoid
arthritis, postoperative pain, dental pain.
Description
Paracetamol acts by reducing production of prostaglandins, which
are involved in the pain and fever processes, by inhibiting the
cyclooxygenase (COX) enzyme .However, there are important
differences between the effects of aspirin and those of
paracetamol. Prostaglandins participate in the inflammatory
response which is why aspirin has been known to trigger symptoms
in asthmatics, but paracetamol has no appreciable
anti-inflammatory action and hence does not have this side-effect.
Furthermore, the COX enzyme also produces thromboxanes, which aid
in blood clotting — aspirin reduces blood clotting, but
paracetamol does not. Finally, aspirin and the other NSAIDs
commonly have detrimental effects on the stomach lining, where
prostaglandins serve a protective role, but paracetamol is safe.
Indeed, while aspirin acts as an irreversible inhibitor of COX and
directly blocks the enzyme's active site, paracetamol indirectly
blocks COX, and this blockade is ineffective in the presence of
peroxides. This might explain why paracetamol is effective in the
central nervous system and in endothelial cells but not in
platelets and immune cells which have high levels of peroxides.
Dosage
1 tablet twice daily.
Presentations
10 tablets
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Quality
