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Each tablet contains
Composition
Nimesulide.....................................................................100
mg
Caffeine............................................................................25mg
Chlorphenamine Maleate.....................................................4mg
Indications
Nimesulide is indicated in musculoskeletal disorders,
dysmenorrhoea, thrombophlebitis, postoperative pain, dental and
ENT inflammation.
Description
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) of the
sulfonanilide class. Its anti-inflammatory, analgesic and
antipyretic activities have been demonstrated in several widely
used animal experimental models and in numerous clinical trials.
Nimesulide only weakly inhibits prostaglandin synthesis and
appears to exert its effects through various mechanisms. It
inhibits the release of oxidants from activated neutrophils and
has a scavenging effect on hypochlorous acid without affecting
neutrophil function. Nimesulide also decreases histamine release
from tissue mast cells and inhibits the production of
platelet-activating factor by human basophils. Furthermore, when
added in vitro to cultures of human articular chondrocytes,
nimesulide inhibits the release of stromelysin and blocks
metalloproteinase activity.
Caffeine acts through multiple mechanisms involving both action on
receptors and channels at the cell membrane, as well as
intracellular action on Calcium and cAMP pathways. By virtue of
its purine structure it can act on some of the same targets as
adenosine related nucleosides and nucleotides, like the cell
surface P1 GPCRs for adenosine, as well as the intracellular
Ryanodine receptor which is the physiological target of cADPR
(cyclic ADP ribose), and cAMP-phosphodiesterase (cAMP-PDE).
Although the action is agonistic in some cases, it is antagonistic
in others. Physiologically, however, caffeine action is unlikely
due to increased RyR opening, as it requires plasma concentration
above lethal dosage. The action is most likely through adenosine
receptors
Dosage
Adults: 100 mg twice daily. Children: 5 mg/kg/day in 2-3 divided
doses.
Presentations
10 tablets
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Quality
