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Each tablet contains
Composition
Nimesulide.......................................................................100
mg
Diclofenac
Sodium............................................................50
mg
Indications
Namosid -D is indicated in musculoskeletal disorders,
dysmenorrhoea, thrombophlebitis, postoperative pain, ental and ENT
inflammation.
Description
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) of the
sulfonanilide class. Its anti-inflammatory, analgesic and
antipyretic activities have been demonstrated in several widely
used animal experimental models and in numerous clinical trials.
Nimesulide only weakly inhibits prostaglandin synthesis and
appears to exert its effects through various mechanisms. It
inhibits the release of oxidants from activated neutrophils and
has a scavenging effect on hypochlorous acid without affecting
neutrophil function. Nimesulide also decreases histamine release
from tissue mast cells and inhibits the production of
platelet-activating factor by human basophils. Furthermore, when
added in vitro to cultures of human articular chondrocytes,
nimesulide inhibits the release of stromelysin and blocks
metalloproteinase activity.
Diclofenac may also be a unique member of the NSAIDs. There is
some evidence that diclofenac inhibits the lipooxygenase pathways,
thus reducing formation of the leukotrienes (also pro-inflammatory
autacoids). There is also speculation that diclofenac may inhibit
phospholipase A2 as part of its mechanism of action. These
additional actions may explain the high potency of diclofenac - it
is the most potent NSAID on a broad basis.
Dosage
Adults: 100 mg twice daily. Children: 5 mg/kg/day in 2-3 divided
doses.
Presentations
10 tablets
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Quality
