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Each uncoated tablet contains
Composition
Misoprostol......................................................................100
mcg
Excipients...............................................................................q.s.
Approved colours used
Indications
Treatment of duodenal, gastric and NSAID induced ulceration.
Misobortol should be taken for the duration of NSAID therapy.
Description
Misoprostol is a synthetic analogue of naturally occurring
prostaglandin E1. It has been approved in more than 90 countries
for prevention and treatment of gastric and duodenal ulcers. Very
few countries have misoprostol registered as an abortion pill. It
is safe and well tolerated, and can be kept at room temperature
when packed in aluminium blisters.
Outcome of treatment with misoprostol when used orally or
vaginally has shown a complete abortion rate of 87% and 95%,
incomplete abortion 3% and 4%, missed abortion 3% and 1% and
continuing pregnancy in 7% and 1% respectively.
Misoprostol is rapidly absorbed after oral administration and
converted to its pharmacologically active metabolite, misoprostol
acid. Plasma concentrations of misoprostol acid peak in
approximately 30 minutes and decline rapidly thereafter.
The effects of misoprostol on the reproductive tract are
increased, and gastrointestinal adverse effects are decreased, if
this is administered vaginally. On vaginal administration, the
plasma concentrations of misoprostol acid peaks in 1-2 hours and
then declines slowly. Vaginal application results in slower
increase and lower peak plasma concentration of misoprostol acid
than does oral administration. Uterine contractility increases and
then plateaus one hour after oral administration, whereas,
contractility continues for four hours after vaginal route.
Dosage
The recommended adult oral dose for the treatment of duodenal,
gastric and NSAID induced ulceration is 200 mcg 4 times daily with
food and at bedtime for 4-8 weeks.
If this dose is not tolerated, a dose of 100 mcg can be used.
Presentations
4 tablets
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Quality
