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Each film-coated tablet contains
Composition
Lamivudine
.....................................................................100
mg
Indications
Lobivir HBV is indicated for the treatment of chronic Hepatitis B
and evidence of hepatitis B virus (HBV) replication in patients
with decompensated liver disease or active inflammation and/or
fibrosis.
Description
Lamivudine (ß-L-2',3'-dideoxy-3'-thiacytidine), one of the
dideoxycytidine (ddC) analogue NRTIs, is the first nucleoside
analogue approved to treat chronic HBV infection and has been
shown to benefit various categories of patients. These include HBe-positive
and -negative patients, non-responders to interferon-{alpha}
therapy, and patients with decompensated cirrhosis.
Lamivudine’s D-isomer is less active against HBV replication and
more cytotoxic than the L-isomer. Both the D- and L-isomers of
2',3'-dideoxy- 3'-thiauridine were found to be inactive against
HBV replication, and the susceptibility of the thiacytidine
stereoisomers to cytidine and/or deoxycytidine deaminase was
suspected to be the reason. In fact, the racemic mixture and the
D-isomer of 2',3'-dideoxy-3'-thiacytidine were deaminated with
partially purified human deaminase and were found to be processed
to the
D-isomer of the thiauridine, while lamivudine and ddC were not.
Despite the intracellular stability of its cytosine base, ddC was
less effective than lamivudine in a cell culture system. Until
recently, it was thought that the potency of lamivudine reflected
the higher incorporation efficiency into newly synthesized DNA by
the viral DNA polymerase. Lamivudine and ddC are phosphorylated to
their triphosphates and then the triphosphates act as chain
terminators during viral and cellular DNA synthesis.
CONTRA-INDICATIONS
EPIVIR Tablets and Oral Solution are contraindicated in
patients with previously demonstrated clinically significant
hypersensitivity to any of the components of the products.
Dosage
The recommended dosage of Lobivir HBV is 100 mg once daily or as
per the physician’s advice.
Presentations
10 tablets
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Quality
