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Ear Drops
Composition
Gentamicin I.P.....................................................
0.3% w/v
Clotrimazole.........................................................1%
w/v
Betamethasone Depropionate U.S.P.......................0.025% w/v
Lignocaine HCL.....................................................2%
w/v
In glycerin I.P & Propylene Glycol I.P......................q.s.
Indications
Gentabet can cause severe hearing and kidney problems. Gentabet
eliminates bacteria that cause many kinds of infections, including
lung, skin, bone, joint, stomach, blood, and urinary tract
infections.
Description
The binding of gentamicin (Gm) to Escherichia coli ribosomes and
ribosomal subunits has been studied. By means of equilibrium
dialysis and of statistical interpretation of the data it was
found that [3H]gentamicin C2 and 6'-N-[3H]methylgentamicin C1a
interact with three classes of sites on tight-coupled 70-S
species: a first class concerning the tight and non-cooperative
interaction with one drug molecule (Kd = 0.6 microM), a second
class in which about five Gm molecules bind cooperatively (mean Kd
= 10 microM), and a third class of very high capacity in which up
to 70 drug molecules may interact. The extreme cooperativity of
the third class of sites induces such an increase in the affinity
for Gm that it may allow the shift of molecules already bound from
high-affinity sites towards lower-affinity sites. The alteration
of a ribosomal protein, L6, in a gentamicin- resistant mutant of
E. coli abolished the multiclass and the cooperative aspects of
ribosomes--gentamicin interaction.
The large ribosomal subunits from E. coli MRE 600 strain interact
cooperatively with Gm, whereas 50-S particles from the resistant
mutant bind the drug in a diffuse way with high capacity and low
affinity. The small subunits from both strains behave identically
towards Gm. A good correlation is observed in comparing the
gentamicin concentrations capable of saturating the different
ribosomal classes of sites with concentrations inducing its
multiphasic effects on protein synthesis.
Dosage
As per the physician’s advice. |