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Each tablet contains
Composition
Frusemide ................................40 mg
Indications
Mild to moderate Hypertension
Description
Frusemide can inhibit various indirectly acting bronchoconstrictor
stimuli in asthmatic patients. Frusemide also modulate airway
neurotransmission in some species but there are no data on the
effect of loop diuretics on neurotransmission in man.The mechanism
of action of frusemide on airway nerves remains unclear:
inhibition of the Na-K-Cl cotransporter is a possibility and, for
frusemide, release of endogenous cyclooxygenase products may be
involved. Carbonic anhydrase inhibition, on the other hand, is
unlikely to be a factor.
This study has provided evidence to support the hypothesis that
frusemide inhibit sensory nerve activation to reduce the itch and
flare responses induced by histamine in human skin in vivo. It is
likely that inhibition of a Na [+]/K [+]/2Cl [-] cotransporter in
the sensory nerve membrane is a possible mechanism of action.
The use of frusemide led to symptomatic improvement shortly after
its administration. They proposed that a 'diuresis' was occurring
through the skin, as their patients did not exhibit increased
urine output before the improvement was noted, but instead seemed
to sweat excessively. The effect of frusemide on veins has been
shown to be mostly an indirect one, but frusemide may also display
direct venodilator properties.
Dosage
Mild to moderate Hypertension: 40-80 mg once or twice daily.
Cardiac, pulmonary, renal, hepatic and cerebral oedema: 20-80 mg
as a single dose daily or on alternate days. Children: 1-2
mg/kg/day as single dose.
Contraindications
Severe sodium and water depletion, hypersensitivity to
sulphonamides and frusemide, hypokalaemia, hyponatraemia,
precomatose states associated with liver cirrhosis, Addison’s
disease.
Presentations
10 tablets
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Quality
