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Composition
Lamivudine.....................................................................150
mg
Zidovudine USP.............................................................300
mg
Indications
Dectrovir is indicated for the treatment of HIV infection, as part
of combination therapy.
Description
Lamivudine is a cytosine analog. After lamivudine is
triphosphorylated, it inhibits HIV reverse transcription via viral
DNA chain termination and inhibits RNA- and DNA-dependent DNA
polymerase activities of reverse transcriptase.
The monophosphate form of lamivudine is incorporated into the
viral DNA by hepatitis B virus polymerase, resulting in DNA chain
termination.
Lamivudine is an analogue of cytidine. It can inhibit both types
(1 and 2) of HIV reverse transcriptase and also the reverse
transcriptase of hepatitis B. It needs to be phosphorylated to its
triphosphate form before it is active. 3TC-triphosphate also
inhibits cellular DNA polymerase.
Lamivudine is administered orally, and it is rapidly absorbed with
a bio-availability of over 80%. Some research suggests that
lamivudine can cross the blood-brain barrier. Lamivudine is often
given in combination with zidovudine, with which it is highly
synergistic. Lamivudine treatment has been shown to restore
zidovudine sensitivity of previously resistant HIV. Several
mutagenicity tests show that lamivudine should not show mutagenic
activity in therapeutical doses.
Zidovudine (Retrovir), formerly known as azidothymidine (AZT), to
inhibit replication of human immunodeficiency virus HIV).
Zidovudine is a member of a class of compounds called
dideoxynucleosides. It is a thymidine analog.
CONTRAINDICATIONS
Dectrovir tablets are contraindicated in patients with previously
demonstrated
clinically significant hypersensitivity to any of the components
of the product.
Warning
Retrovir (zidovudine) has been associated with hematologic
toxicity including neutropenia and severe anemia particularly in
patients with advanced human immunodeficiency virus (hiv) disease
(see warnings). prolonged use of retrovir has been associated with
symptomatic myopathy.
Dosage
The recommended oral dose of Dectrovir for adults and adolescents
(at least 12 years of age) is one tablet (containing 150 mg of
lamivudine and 300 mg of zidovudine) twice daily with or without
food or as per the physician’s advice.
Presentations
10 tablets
60 tablets (Container) |
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Quality
