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USE
Deprexx ® is an antidepressant medication that affects
chemicals within the brain that nerves use to send messages to
each other. These chemical messengers are called
neurotransmitters. Many experts believe that depression is
caused by an imbalance among the amounts of neurotransmitters that
are released. Nerves, in a process referred to as reuptake, may
recycle released neurotransmitters. Deprexx ® works by inhibiting
the reuptake of dopamine, serotonin, and norepinephrine; an action
that results in more dopamine, serotonin, and norepinephrine to
transmit messages to other nerves.
DOSING
Deprexx ® usually is given in one, two or three daily
doses. For immediate-release tablets, no single dose should exceed
150 mg and each dose should be separated by 6 hours.
For depression the recommended dose of immediate-release tablets
is 100 mg 3 times daily (300 mg/day); maximum dose is 450 mg
daily. The initial dose is 100 mg twice daily. The dose may be
increased to 100 mg 3 times daily after three days.
The initial dose of sustained-release tablets is 150 mg daily;
target dose is 150 mg twice daily; maximum dose is 200 mg twice
daily.
The initial dose of extended-release tablets is 150 mg daily;
target dose is 300 mg daily; maximum dose is 450 mg daily.
Extended release tablets are administered once daily.
When used for smoking cessation, Deprexx ® usually is started
as 150 mg once daily for three days, and then the dose is
increased if the patient tolerates the starting dose. Smoking is
discontinued two weeks after starting Deprexx ® therapy.
Side Effects
* drowsiness
* excitement
* dry mouth
* dizziness
* headache
* nausea
* vomiting
* uncontrollable shaking of a part of the body
* weight loss
* constipation
* excessive sweating
Some side effects can be serious
* seizures
* confusion
* hallucinating (seeing things or hearing voices that do not
exist)
* irrational fears
* fever
* rash or blisters
* itching
* hives
* swelling of the face, throat, tongue, lips, eyes, hands, feet,
ankles, or lower legs
* hoarseness
* difficulty breathing or swallowing
* chest pain
* muscle or joint pain
* rapid, pounding, or irregular heartbeat
STORAGE
Deprexx ® Tablets should be
kept at room temperature, 15-25°C (59-77°F).
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Quality
