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Each 5 gm contains
Composition
Triclosan, Silica, Special Flavour.
Indications
Twice Brushing with Dr. Dentist, gently removes tough stain, long
lasting mint flavour keeps mouth clean & fresh, no harsh aprasives
or bleach.
Description
Triclosan is a broad-spectrum antibacterial agent that inhibits
bacterial fatty acid synthesis at the enoyl-acyl carrier protein
reductase (FabI) step. Resistance to triclosan in Escherichia coli
is acquired through a missense mutation in the fabI gene that
leads to the expression of FabI[G93V]. The specific activity and
substrate affinities of FabI[G93V] are similar to FabI. Two
different binding assays establish that triclosan dramatically
increases the affinity of FabI for NAD+. In contrast, triclosan
does not increase the binding of NAD+ to FabI[G93V]. The x-ray
crystal structure of the FabI-NAD+-triclosan complex confirms that
hydrogen bonds and hydrophobic interactions between triclosan and
both the protein and the NAD+ cofactor contribute to the formation
of a stable ternary complex, with the drug binding at the enoyl
substrate site. These data show that the formation of a
noncovalent "bi-substrate" complex accounts for the effectiveness
of triclosan as a FabI inhibitor and illustrates that mutations in
the FabI active site that interfere with the formation of a stable
FabI-NAD+-triclosan ternary complex acquire resistance to the
drug.
Dosage
As per the physician’s advice or Dentist Doctor’s advices.
Presentations
100 gm
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Quality
