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Each tablet
contains:
Composition: Each tablet of COMBIPAR contains:
Ibuprofen …......................... 400 mg
Paracetamol …................... 500 mg
Each tablet of COMBIPAR KID contains:
Ibuprofen …........................ 100 mg
Paracetamol ….................. 125 mg
Therapeutic Indications & Usage :
COMBIPAR is indicated for mild to moderate pain associated with
inflammation.
Contraindications : COMBIPAR is not advocated for those allergic to its
ingredients, history of hypersensitivity to aspirin or other
NSAIDs, aspirin-induced nasal polyps or bronchospasm, active
peptic ulceration and in severe renal dysfunction.
Precautions & Warnings : COMBIPAR is to be advocated with caution in liver & kidney
damage, elderly, patients requiring surgery, anemia, bronchial
asthma, stomatitis, compromised cardiac function, heart failure,
pre-existing edema, systemic lupus erythematosus.
Safe use of COMBIPAR in pregnancy and lactation has not been
established. COMBIPAR should not be preferably coadministered with
other NSAIDs, corticosteroids, hypoglycemics, digoxin, lithium,
methotrexate, cyclosporine, coagulants & anticoagulants, bone
marrow suppressants as well as probenecid.
Adverse Reactions : The adverse reactions due to ibuprofen (in COMBIPAR) include
cardiovascular manifestations (tachycardia, flushing & increase in
blood pressure), GI complaints (particularly epigastric
discomfort, ulceration & perforation), skin changes,
hypersensitivity reactions, renal affections, aphthous stomatitis,
gingival ulcerations, vision abnormalities, change in hearing,
epistaxis, pancreatitis, hepatitis and hematological disturbances.
Side Effects of Paracetamol : (in COMBIPAR) are rare, and usually mild. Skin rashes and
other hypersensitivity reactions could occur, and, on rare
occasions, paracetamol could cause hematological changes.
Drug Interaction : Corticosteroids along with ibuprofen can enhance GI damage.
Anticoagulants, heparin or thrombolytic agents are dangerous
during COMBIPAR intake in view of ibuprofen's potential to cause
GI ulceration / bleeding. Ibuprofen (in COMBIPAR) can increase the
hypoglycemic action of oral antidiabetics and insulin.
When given along with antihypertensives or agents with potential
to suppress bone marrow (like some cephalosporins), ibuprofen can
increase risk of edema and hematopoietic disturbances
respectively. Ibuprofen (in COMBIPAR) can increase plasma
concentrations of digoxin, cyclosporine, lithium and methotrexate.
Absorption of paracetamol from COMBIPAR is increased by
concomitant metoclopramide, and such other agents. Probenecid can
decrease it clearance and thereby increase paracetamol's plasma
half-life whengiven along with COMBIPAR.
Recommended Dosage & Administration : Adults: 1 COMBIPAR Tab tid/qid, or as prescribed.
Children (ibuprofen: 20-30 mg/kg body
weight per day in divided doses;
paracetamol: 10-15 mg/kg body weight upto 4 times daily) 0.5-1 yr: ˝ COMBIPAR KID Tab
tid.
1-2 yrs: ˝ COMBIPAR KID Tab tid /
qid.
3-7 yrs: 1 COMBIPAR KID Tab tid /
qid.
8-12 yrs: 2 COMBIPAR KID Tabs tid
/ qid.
Presenations :
COMBIPAR Tablets : Blisters of 10s.
COMBIPAR KID Tablets : Blisters of 10s.
Each tablet of DUOFLAM PLUS contains: Ibuprofen …................................400 mg
Paracetamol …......................... 500 mg
Caffeine (anhydrous) ….......... 25 mg
Note :This product
information is intended only for residents of the India.
Taj Pharmaceuticals Limited, medicines help to treat and prevent
a range of conditions—from the most common to the most
challenging—for people around the world.
Information for Health Care Professionals
*** Please consult local Prescribing
Information for any product before use. This website is an
international information resource for healthcare professionals
with an interest in disease management. This website is not
intended to replace the advice of a qualified healthcare
professional. Above brand is a trademark of the Taj group of
companies (Taj Pharmaceuticals Limited).