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Composition
Cetirizine Dihydrochloride ….
.................................. 10 mg
Excipients.
.................................................................q.s.
Indications
Cetrilin is indicated in the treatment of perennial and seasonal
allergic rhinitis pruritus, allergic asthma, allergic
conjunctivitis and urticaria.
Description
An antihistamine is a drug serves to reduce or eliminate effects.
which serves to reduce or eliminate effects mediated by histamine.
an endogenous chemical mediator released during allergic
reactions. Only agents where the main therapeutic effect is
mediated by negative modulation of histamine receptors are termed
antihistamines - other agents may have antihistaminergic action
but are not true antihistamines. In common use, the term
antihistamine refers only to H1-receptor antagonists, also known
as H1-antihistamines.
In allergic reactions an allergen (a type of antigen) interacts
with and cross-links surface IgE antibodies on mast cells and
basophils. Once the mast cell-antibody-antigen complex is formed,
a complex series of events occurs that eventually leads to cell-degranulation
and the release of histamine (and other chemical mediators) from
the mast cell or basophil. Once released, histamine can react with
local or widespread tissues through histamine receptors.
Histamine, acting on H1-receptors, produces pruritis, tachycardia
bronchoconstriction
increases vascular permeability, potentiates pain.While
H1-antihistamines ameliorate these effects, it is only efficacious
if administered prior to the allergen-challenge. In severe
allergies, such as anaphylaxis or angioedema, these effects may be
so severe as to be life-threatening. Epinephrine
often in the form of an autoinjector (Epi-pen), is required by
people with such hypersensitivities.
Contraindications
Patients who are hypersensitive to any component of this product
or to montelukast sodium, levocetirizine or cetirizine. Patients
with completely impaired renal function (anuria).
Precautions
Precaution is recommended with intake of alcohol.
Patients with rare hereditary problems of galactose intolerance,
the Lapp lactase deficiency or glucose-galactose malabsorption
should not take this medicine.
Dosage and Administration
Adults and children (above 12 years): One tablet daily. The
maximum
recommended dose is two tablets daily.
Presentations
10 tablets
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Quality
