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Each Uncoated Tablet Contains:-
Composition
Adefovir Dipivoxil……..10mg
Approved colours used
Indications
Adevera® (adefovir dipivoxil) is a prescription medicine used to
treat chronic infection with H - B virus (HBV) adeverain adults. Adevera does not cure chronic Hepatitis B, and it does not reduce
the risk of spreading Hepatitis B to others. An antiviral
medicine, Adevera helps stop H - B virus (HBV) from multiplying by
blocking HBV DNA polymerase, an enzyme that is necessary for the
replication of the virus in the body.
Description
Adefovir works by blocking reverse transcriptase, an enzyme that
is crucial for the hepatitis B vvirus (HBV) to reproduce in the
body. It is approved for the treatment of chronic hepatitis B in
adults with evidence of active viral replication and either
evidence of persistent elevations in serum aminotransferase
(primarily ALT) or histologically active disease. Adefovir is a
failed treatment for HIV due to the severity and frequency of
kidney toxicity when dosed at 60 or 120 mg. However, trials have
found the 10 mg dose of adefovir to be an effective and safe
treatment for HBV.The main benefit of adefovir over lamivudine
(the first NRTI approved for the treatment of hepatitis B) is that
it takes a much longer period of time before the virus develops
resistance to it.
Dosage
Adevera® (adefovir dipivoxil) is provided as a 10 mg tablet that
you take once a day by mouth. Adevera can be taken with or without
food. If you have or develop kidney problems, your doctor may tell
you to take the pill on a different schedule.
Overdose
Doses of adefovir dipivoxil 500 mg daily for 2 weeks and 250 mg
daily for 12 weeks have been associated with gastrointestinal side
effects effects. If overdose occurs the patient occurs the
patients must be monitored for evidence of toxicity, and standard
supportive treatment applied as necessary.
Following a 10 mg single dose of of HEPSERA, a four-hour
hemidialysis session removed approximately 35% of the adefovir
dose.
Contraindications
HEPSERA is contraindicated in patients with previously
demonstrated hypersensitivity to any of the components of the
product.
Presentations
30 tablets PVC Bottle with carton
Adevera® Blister pack of 10 capsules |
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Quality
