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Each tablet contains
Composition
Albendazole....................................................................400
mg
Indications
ZENTIC-400 is indicated in the treatment of hookworm (ancyclostoma,
necator), roundworm (ascaris), threadworm (strongyloides),
whipworm (trichuris), tapeworm (taenia species), opisthorchis,
hydatid disease (echinococcus),neurocysticercosis, mixed
helminthic infestations.
Description
Albendazole causes degenerative alterations in the tegument and
intestinal cells of the worm by binding to the colchicine-sensitive
site of tubulin, thus inhibiting its polymerization or assembly
into microtubules. The loss of the cytoplasmic microtubules leads
to impaired uptake of glucose by the larval and adult stages of
the susceptible parasites, and depletes their glycogen stores.
Degenerative changes in the endoplasmic reticulum, the
mitochondria of the germinal layer, and the subsequent release of
lysosomes result in decreased production of adenosine triphosphate
(ATP), which is the energy required for the survival of the
helminth. Due to diminished energy production, the parasite is
immobilized and eventually dies.
Dosage
Adults and children over two years: 1 tablet or 10 ml suspension
(400 mg) as a single dose. In strongyloides or H. nana
infestations, 1 tablet or 10 ml suspension once daily for 3 days.
Children (1-2 years): One half tablet or 5 ml suspension (200 mg)
as a single dose. The tablet must be chewed, swallowed or crushed
and mixed with food.
Presentations
1 tablet
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Quality
