Composition

 Packing

Expiry

3 Yrs

Milrinone 10mg/10ml solution for injection ampoules

Milrinone (Mill-rin-own) is a medicine which is used in heart failure.

The information in this Medicine Guide for Milrinone varies according to the condition being treated and the particular preparation used.



Quick links

- How to use your medicine – includes taking, storing and stopping your medicine, what to do if you take too much, plus the ingredients of your medicine.
- Warnings – covers the suitability of the medicine for you and side effects and interactions with other medicines.
- Your medicine and everyday activities – includes alcohol, your diet, complementary medicines and vitamins as well as driving.
- Family planning – provides advice about whether this medicine is suitable for you in pregnancy and breast feeding.

Your medicine

Milrinone relaxes blood vessels and increases the force with which the heart contracts. It is used to treat heart failure.

Milrinone is usually given to you by a healthcare professional. The person responsible for giving you your medicine will make sure that you get the right dose.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber or someone involved in your medical care.

When to take your medicine

The person with responsibility for giving you your medicine will make sure that you have your medicine at the prescribed times.

How to take your medicine

This medicine will be given to you as an injection. If you have any concerns about this medicine or how this will be given to you, talk to someone who is involved in your medical care.

Taking too much of your medicine

Having extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems.

In the case of Milrinone, the person who is responsible for giving you your medicine will make sure that you are given the correct dose.

Stopping your medicine

The person in charge of your care will make the decision about when you should stop this medicine. If you experience any problems while using this medicine, talk to someone who is involved in your medical care.

Looking after your medicine

As Milrinone will be given to you as an injection, it will usually be stored by the medical team.

Whether this medicine is suitable for you

Milrinone is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
have hypovolaemia
have kidney problems
have metabolic problems
have risk factors for developing bleeding in the brain
have, have had or have risk factors for developing certain types of heart problems

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for premature infants or neonates with low birth weight.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

to check that this medicine is not having any undesired effects
to determine whether or not the medicine is suitable and whether it must be prescribed with extra care

Over time it is possible that Milrinone can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Milrinone has become unsuitable, it is important that the prescriber is contacted immediately.

Side-effects

A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.
Common: More than 1 in 100 people who use Milrinone:

headaches
heart rhythm problems
lowered blood pressure

Uncommon: More than 1 in 1000 people who use Milrinone:

abnormal laboratory test results
angina
blood and bone marrow problems
chest pain
metabolic problems
tremors

Very rare: Fewer than 1 in 10,000 people who use Milrinone:

anaphylactic shock
bronchospasm
skin problems such as rashes

The frequency of these side-effects is unknown:

bleeding in the brain in neonates or premature infants
injection site problems - seek medical advice if any symptoms occur
patent ductus arteriosus in neonates or premature infants - this may be fatal

If you feel unwell or if you have concerns about a side-effect, tell the person looking after you immediately.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Milrinone:

digoxin

The following types of medicine may interact with Milrinone:

calcium channel blockers
digitalis glycosides
diuretics

If you are taking Milrinone and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Milrinone.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

Like all medicines Milrinone can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

Diet

Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Milrinone:

there are no specific foods that you must exclude from your diet when using Milrinone

Alcohol

Alcohol can interact with certain medicines.

In the case of Milrinone:

there are no known interactions between alcohol and Milrinone

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Milrinone:

you should only use this medicine during pregnancy if your doctor thinks that you need it

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Milrinone, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

Breast-feeding

Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Milrinone:

women who are breast-feeding must not use this medicine

Before you have your baby you should discuss breast-feeding with your doctor or midwife. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed.

Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They may also be used to prolong the life of the medicine.

This medicine contains milrinone.

We are unable to list all of the ingredients for your medicine here. For a full list, you should refer to the patient information leaflet that comes with this medicine or ask your prescriber. You should check that you are able to take the ingredients of your medicine, especially if you have any allergies.

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Milrinone before, do not take Milrinone. Talk to your prescriber, pharmacist or nurse as soon as possible.



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