Generic Name: VERAPAMIL HYDROCHLORIDE
Brand Name: VERAPAMIL HYDROCHLORIDE SR
Active ingredients:
VERAPAMIL HYDROCHLORIDE
COMPOSITION:
Each slow release tablet contains 240 mg verapamil
hydrochloride.
IDENTIFICATION:
Yellow capsule-shaped tablet scored.
PHARMACOLOGICAL ACTION:
Verapamil is a calcium ion influx inhibitor (slow,
channel blocker or slow calcium ion antagonist)
which exerts its pharmacological effects by
modulating the influx of ionic calcium across cell
membranes of the arterial smooth muscle as well as
in conductile and contractile myocardial cells.
Verapamil reduces myocardial oxygen consumption in
vitro directly by intervening in the energy
consuming metabolic processes of the myocardial
cell, and indirectly by diminishing the peripheral
resistance (afterload). It prolongs impulse
conduction in the AV node.
INDICATIONS:
Angina pectoris, mild to moderate hypertension,
supraventricular tachydysrhythmia.
Prophylaxis of supraventricular relapses after
electrocardioversion.
WARNINGS:
Heart Failure: Verapamil has a negative
inotropic effect which, in most patients, is
compensated by its after load reduction (decreased
systemic vascular resistance) properties without a
net impairment of ventricular performance. Verapamil
should be avoided in patients with severe left
ventricular dysfunction and in patients with any
degree of ventricular dysfunction if they are
receiving a beta-adrenergic blocker. Patients with
milder ventricular dysfunction should, if possible,
be controlled with optimal doses of digitalis and/or
diuretics before verapamil treatment.
Hypotension: Verapamil may produce
symptomatic hypotension in normotensive patients.
Elevated liver enzymes: Elevation of
transaminases with and without concomitant
elevations in alkaline phosphatase and bilirubin
have been reported.
Accessory bypass tract (Wolff-Parkinson-White or
Lown-Ganong-Levine): Some patients with
paroxysmal and/or chronic atrial fibrillation or
atrial flutter and a coexisting accessory AV pathway
have developed an increased anterograde conduction
across the accessory pathway bypassing the AV node,
producing a very rapid ventricular response or
ventricular fibrillation after receiving intravenous
verapamil. Patients receiving oral verapamil may be
at risk.
Atrioventricular block: The effect of
verapamil on AV conduction and the SA node may lead
to asymptomatic first-degree AV block and transient
bradycardia, sometimes accompanied by nodal escape
rhythms. PR interval prolongation is correlated with
verapamil plasma concentration, especially during
the early titration phases of therapy. Marked
first-degree block or progressive development to
second or third-degree AV block requires a reduction
in dosage or, in some instances, discontinuation of
the medicine.
Patients with hypertrophic cardiomyopathy (HSS):
A variety of serious adverse effects can occur in
patients with hypertrophic cardiomyopathy, pulmonary
oedema and/or severe hypotension, sinus bradycardia,
AV block and sinus arrest.
DOSAGE AND DIRECTIONS FOR USE:
The doses as prescribed by the doctor are to be
taken regularly. The tablets are to be swallowed
whole with some liquid, preferable with or shortly
after meals.
Angina pectoris and supraventricular dysrhythmia:
Half to one tablet every 12 hours.
Hypertension: One tablet per day (preferably
in the morning).
If the desired response is not obtained in 7 days,
the dose may be increased to one tablet in the
morning, and half a tablet at night. The maximum
recommended dose is one tablet every 12 hours.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Constipation, headache, fatigue, palpitations, first
and second degree AV block, SA block, epigastric
pain, flush, dizziness, urticaria and temporary skin
rash may occur. Reports of individuals experiencing
exacerbation of arthritis, increased urination,
burning sensations of the gums, mild tremor and
severe facial pain are known.
Use in patients with impaired hepatic function:
Since verapamil is highly metabolised by the liver,
it should be administered cautiously to patients
with impaired hepatic function. Severe liver
dysfunction prolongs the elimination half-life of
immediate-release verapamil to about 15 hours;
hence, approximately 30% of the dose given to
patients with normal liver function should be
administered to these patients. Careful monitoring
for abnormal prolongation of the PR interval or
other signs of excessive pharmacological effects
should be carried out.
Use in patients with attenuated neuromuscular
transmission: It has been reported that
verapamil decreases neuromuscular transmission in
patients with Duchenne’s muscular dystrophy, and
that verapamil prolongs recovery from the
neuromuscular blocking agent vecuronium. It may be
necessary to decrease the dosage of verapamil when
it is administered to patients with attenuated
neuromuscular transmission.
Use in patients with impaired renal function:
About 70 % of an administered dose of verapamil is
excreted as metabolites in the urine. Verapamil is
not removed by haemodialysis. Until further data are
available, it should be administered cautiously to
patients with impaired renal function. These
patients should be carefully monitored for abnormal
prolongation of the PR interval or other signs of
overdosage.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF
ITS TREATMENT:
Bradycardia, hypotension, atrioventricular
dissociation, hyperglycaemia.
Treatment is symptomatic and supportive.
STORAGE INSTRUCTIONS:
Store at room temperature (below 25°C) protect from
light and moisture.Keep out of reach of children.
**** ALL PRODUCTS ARE ONLY AVAILABLE ON GENERIC
NAME.
BENACOLD & REXAFED ARE THE REGISTRED BRANDS © OF TAJ
GROUP- PHARMA DIVISION
Taj Pharmaceuticals logo Copyright © 2004-2011 Taj
Pharmaceuticals Limited. All rights reserved. Legal
Notice
The products discussed herein may have different
product labeling in different countries. The product
information provided in this site is intended only
for the residents of India.
**** NOTE.
23 PRODUCTS EXCLUSIVE FOR ISRAEL MARKET
DOWNLOAD
PRODUCT LIST
|