GENERIC NAME:
VENLAFAXINE HYDROCHLORIDE
Active ingredients:
VENLAFAXINE HYDROCHLORIDE
VENLAFAXINE HYDROCHLORIDE
37.5mg, 75mg, 150mg
ALSO AVIAL:
SR TABLETS IN SAME. (Slow Release Tablets)
Pharmacology:
Potentiates norepinephrine, serotonin, and dopamine
neurotransmitter activity in the CNS by inhibiting
their neuronal reuptake.
IDENTIFICATION:
Color:
Light Orange
Shape:
Circle
Pattern:
Speckled ,SCORED
Generalized anxiety disorder;
panic disorder.
Unlabeled Uses:
Autism; binge eating disorder; hot flashes; pain;
premenstrual dysphoric disorder; posttraumatic
stress disorder; prevention of migraine.
Pharmacology:
Potentiates norepinephrine, serotonin, and dopamine
neurotransmitter activity in the CNS by inhibiting
their neuronal reuptake.
Absorption:Absolute
bioavailability is 45% and a single oral dose is
well absorbed (at least 92%). Steady-state
concentrations of venlafaxine and O-desmethylvenlafaxine
(ODV) in plasma are attained within 3 days of oral
dosing.
Metabolism:
Extensively metabolized in the liver. The major
metabolite is ODV, which is active.
Elimination:Renal
elimination of venlafaxine and its metabolite is the
primary route of excretion. Within 48 h, 87% is
recovered in urine. Elimination half-life is 5 h (11
h for ODV).
Renal Function Impairment:
Dosage adjustment is necessary with CrCl 10 to 70 mL/min.
Venlafaxine elimination half-life was prolonged
approximately 50% and Cl was reduced approximately
24%; ODV elimination half-life was prolonged 40%
although Cl was unchanged.
Dialysis:
Dose adjustment is necessary. Venlafaxine
elimination half-life was prolonged approximately
180% and Cl was reduced approximately 57%. ODV
elimination half-life was prolonged approximately
142% and Cl was reduced 56%.
Hepatic Function Impairment: In patients with hepatic cirrhosis, dosage adjustment is
necessary. Venlafaxine elimination half-life was
prolonged by approximately 30% and Cl decreased 50%;
ODV elimination half-life was prolonged
approximately 60% and Cl decreased 30%.
Elderly:
Pharmacokinetics not altered by age.
Gender:
Pharmacokinetics not altered by gender.
Poor/Extensive metabolizers:Venlafaxine plasma concentrations were higher in CYP2D6 poor
metabolizers than in extensive metabolizers. AUC of
venlafaxine and ODV were similar in poor and
extensive metabolizers. No dosage adjustment is
required.
Contraindications: Concomitant use with MAOIs; hypersensitivity to venlafaxine
or any component in the formulation.
General Advice:
* It is generally agreed that acute episodes of MDD require
several months or longer of sustained
pharmacological therapy beyond response to the acute
episode.
* Swallow venlafaxine capsules or
tablets whole. Do not divide, crush, chew, or place
in water.
* For patients who have difficulty
swallowing venlafaxine capsules whole, the capsules
may be opened and the contents sprinkled on a
spoonful of applesauce. The drug/applesauce mixture
should be swallowed immediately without chewing and
followed with a glass of water. Do not prepare the
mixture ahead of time and store.
Adverse Reaction:
Major Depressive Disorder - Adverse
events in short-term studies that occurred in at
least 5% of the patients receiving venlafaxine
extended-release capsules and at a rate at least
twice that of the placebo group were abnormal
ejaculation, gastrointestinal complaints (nausea,
dry mouth, and anorexia), CNS complaints (dizziness,
somnolence, and abnormal dreams), and sweating.
Dosing:
-
Should be administered in a single dose with
food either in the morning or in the evening at
approximately the same time each day
-
Each capsule should be swallowed whole with
fluid and not divided, crushed, chewed, or
placed in water, or it may be administered by
carefully opening the capsule and sprinkling the
entire contents on a spoonful of applesauce;
this drug/food mixture should be swallowed
immediately without chewing and followed with a
glass of water to ensure complete swallowing of
the pellets
-
Flexibility in dosing for depression
-
Patients not responding to the initial dose
of 75 mg/day may benefit from increases to a
maximum of approximately 225 mg/day
-
When increasing the dosage, incremental
increases of up to 75 mg/day should be made
at intervals of no less than 4 days
-
Experience with doses higher than 225 mg/day
is very limited
-
Dosing for special populations may vary.
Storage:
Store between 68° and 77°F. Protect from
moisture.Protect from
Sunlight and Heat.
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product labeling in different countries. The product
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