Generic Name:
CICLOSPORIN
Active Ingredient:
CICLOSPORIN
CICLOSPORIN
TABLET 25mg, 50mg, 100mg.
Indication and usage:
-
Prevention of organ or tissue rejection
following kidney, liver, heart, lung, combined
heart-lung, pancreas or bone marrow transplants.
-
Treatment of transplant rejection in people
previously receiving other immunosuppressants.
-
Prevention and treatment of graft-versus-host
disease, where the cells from transplanted bone
marrow tissue attack the cells of the transplant
recipient.
-
A syndrome caused by kidney inflammation, characterised by a large amount of protein in
the urine, swelling, weight gain and high blood
pressure (nephrotic syndrome).
-
Short-term treatment (eight weeks) of severe atopic dermatitis (eczema) for which
conventional treatments are ineffective or
inappropriate.
-
Severe psoriasis for which conventional
treatment is ineffective or inappropriate.
-
Severe rheumatoid arthritis for which
conventional disease-modifying antirheumatic
drugs (DMARDs) are ineffective or inappropriate.
Warnings!
-
Neoral capsules should be swallowed whole with a
mouthful of water. Neoral oral solution doses
should be diluted before taking, either with
water, or alternatively with orange juice/squash
or apple juice to improve the taste. Stir the
mixture well and drink at once. Neoral oral
solution should never be diluted with grapefruit
juice.
-
You should not eat grapefruit or drink
grapefruit juice in the hour before taking your
dose of Neoral capsules or Neoral oral solution,
as this can increase the amount of medicine that
is absorbed into the bloodstream.
-
The measuring device for Neoral oral solution
should not be allowed to come into contact with
the liquid you use to dilute your dose. The
measuring device should not be rinsed with
water, alcohol or any other liquid. If it is
necessary to clean it, the outside should be
wiped with a dry tissue.
-
This medicine can cause the amount of potassium
in your bloodstream to increase. For this reason
you should avoid consuming large amounts of
foods that have a high potassium content, for
example dried fruit, bananas, tomatoes and 'low
sodium' salt, while you are taking the medicine.
You should also avoid potassium supplements and
certain other medicines - see the end of this
factsheet for more details.
-
You will need to have regular blood tests to
monitor your kidney and liver function and the
level of potassium and lipids in your blood
while you are taking this medicine.
-
This medicine increases your susceptibility to
infections because the suppressed immune system
is less able to fight them. For this reason,
consult your doctor immediately if you develop a
sore throat, any infections, or begin to feel
generally unwell.
-
People having long-term or intense
immunosuppressive treatment are at increased
risk of developing lymphomas and other cancers,
particularly skin cancer. To reduce the risk of
skin cancer you should minimise your exposure to
strong sunlight and UV light by wearing
protective clothing and using a sunscreen with a
high protection factor.You should avoid sun beds
and excessive unprotected sun exposure. Discuss
this with your doctor.
-
If you are taking this medicine for psoriasis or
dermatitis you should not receive light
treatment, such as PUVA, or other UV light
treatment, while taking this medicine.
-
Your blood pressure should be regularly
monitored while you are taking this medicine. If
your blood pressure rises too high you may be
prescribed a medicine to lower it.
Use with caution in:
-
Children.
-
Elderly people.
-
Decreased kidney function.
-
People with a high level of uric acid in their
blood (hyperuricaemia).
-
Dermatitis patients with skin infections.
-
Dermatitis and psoriasis patients with malignant
(cancerous) or pre-malignant skin conditions.
Not to be used in
-
Nephrotic syndrome patients with uncontrolled
high blood pressure, uncontrolled infections, or
any kind of malignancy (cancer).
-
Psoriasis and dermatitis patients with abnormal
kidney function, uncontrolled high blood
pressure, uncontrolled infections or any kind of
malignancy (except of the skin).
-
Rheumatoid arthritis patients under 18 years of
age.
-
Rheumatoid arthritis patients with abnormal
kidney function, uncontrolled high blood
pressure, uncontrolled infections, or any kind
of malignancy.
This medicine should not be used if you are allergic
to one or any of its ingredients. Please inform your
doctor or pharmacist if you have previously
experienced such an allergy.
If you feel you have experienced an allergic
reaction, stop using this medicine and inform your
doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during
pregnancy or breastfeeding. However, other medicines
may be safely used in pregnancy or breastfeeding
providing the benefits to the mother outweigh the
risks to the unborn baby. Always inform your doctor
if you are pregnant or planning a pregnancy, before
using any medicine.
-
The safety of this medicine for use during
pregnancy has not been established. It is not
recommended for use in pregnancy unless
considered essential by your doctor. Seek
medical advice from your doctor.
-
This medicine passes into breast milk and women
taking this medicine should therefore not
breastfeed. Seek medical advice from your
doctor.
Side effects:
-
Shaking, usually of the hands (tremor).
-
Headache.
-
Increase in the level of fats eg cholesterol in
the blood (hyperlipidaemia).
-
High blood pressure (hypertension).
-
Decreased kidney function.
-
Infections of the lungs and airways or urinary
tract.
Dose:
The recommended starting dose is 2.5mg/kg/day in two
divided doses for the first six weeks. The starting
dose may be reduced to 1.0 mg/kg if required. If the
clinical effect is insufficient, the dose may then
be gradually increased until clinically effective,
toxicity occurs, or a maximum dose of 4mg/kg/day is
reached.
STORAGE:
Store below 25°C-30°C depending on the formulation.
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