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Each tablet contais
Composition
Artesunate
......................................................................50
mg
Indications
Cerebral malaria, Chloroquine resistant malaria, Plasmodium
falciparum malaria, Severe malaria.
Description
Artesunate and its active metabolite dihydroartemisinin are potent
blood schizonticides, active against the ring stage of the
parasite. It is effective against P. falciparum resistant to all
other antimalarial drugs. It does not have hypnozoiticidal
activity. It reduces gametocyte carriage rate.
The functional group responsible for antimalarial activity of
artesunate is endoperoxide bond. Release of an active oxygen
species from this bond kills the parasite if accumulated in the
erythrocytic cells.
It also suppresses the production or activity of antioxidant
enzymes in the erythrocytes.
CONTRAINDICATIONS
The drug is contraindicated in patients with prior
hypersensitivity to artesunate or artemisinin derivatives,
pyrimethamine or sulphonamides. The drug is also contraindicated
in patients with severe renal insufficiency, marked liver
parenchymal damage or blood dyscrasias, patients with documented
megaloblastic anemia due to folate deficiency, infants < 2 months
of age, pregnancy and during the nursing period.
Dosage
Adults: Total oral dose of 600mg is recommended which can be
divided into two tab. (100mg) bd on the first day followed by 1
tab. (50mg) bd for next four days.
Children: Half the adult dose in the above manner.
Presentations
4 tablets
1 vial
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Quality
