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Each capsule (E.C. granules ) contains
Composition
Omeprazol..................................................................20
mg
Indications
Ulcer, duodenal; Adenoma, multiple endocrine; Esophagitis,
erosive; Gastroesophageal Reflux Disease; Mastocytosis, systemic;
Ulcer, gastric; Zollinger-Ellison syndrome; Pregnancy Category C
Description
Omeprazole is a selective and irreversible proton pump inhibitor.
Omeprazole suppresses gastric acid secretion by specific
inhibition of the hydrogen–potassium adenosinetriphosphatase (H +,
K +-ATPase) enzyme system found at the secretory surface of
parietal cells. It inhibits the final transport of hydrogen ions
(via exchange with potassium ions) into the gastric lumen. Since
the H +, K +-ATPase enzyme system is regarded as the acid (proton)
pump of the gastric mucosa, omeprazole is known as a gastric acid
pump inhibitor. The inhibitory effect is dose-related. Omeprazole
inhibits both basal and stimulated acid secretion irrespective of
the stimulus.
Side/Adverse Effects
Note: Gastric fundic gland polyps have occurred rarely in patients
receiving omeprazole; these appear to be benign and reversible
upon discontinuance of omeprazole.
Gastroduodenal carcinoids have been reported in patients with
Zollinger-Ellison syndrome who have received long-term omeprazole
therapy. These carcinoids are believed to be a manifestation of
the underlying syndrome, which is known to be associated with such
tumors.
Atrophic gastritis has been noted occasionally in gastric corpus
biopsies from patient receiving long-term omeprazole therapy.
Overt liver disease has occurred rarely, and included
hepatocellular, cholestatic, or mixed hepatitis, liver necrosis
(sometimes fatal), hepatic failure (sometimes fatal), and hepatic
encephalopathy.
The following side/adverse effects have been selected on the basis
of their potential clinical significance (possible signs and
symptoms in parentheses where appropriate)—not necessarily
inclusive
Contraindications
Omeprazole delayed-release capsules are contraindicated in
patients with known hypersensitivity to any component of the
formulation
Dosage
As per the physician’s advice.
Presentations
10 caps
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Quality
