Drug description : Tablets.

Indications :
Parkinsonism, alone or in combination with levodopa.

Adult Dosage :
10mg daily as a single dose in the morning or in divided doses at breakfast and lunch.

Elderly Dosage :
Initial dose of 2.5mg daily may be advisable in the elderly to avoid initial confusion and agitation.

Special Precautions :
Peptic ulceration, uncontrolled hypertension, arrhythmias, angina, psychosis. Pregnancy and lactation. May potentiate side effects of levodopa; may need to reduce dose of levodopa by 20 to 50 per cent.

Interactions :
Fluoxetine, sertraline, paroxetine, pethidine, non- selective MAOIs, tricyclic antidepressants.

Adverse Reactions :
Postural hypotension, headache, arrhythmias, vertigo, involuntary movements, nausea and vomiting, confusion or psychosis, agitation, dry mouth. Liver enzyme disturbances. Difficulty in micturition and skin reactions also reported.

       For more information, please see Full Prescribing Information.

 

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