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Description :
Paracetamol tablets, syrupand drops for oral administration
provide paracetamol, a widely used, non-narcotic, non-salicylate,
analgesic and antipyretic of high efficacy. When administered in
usual therapeutic dosages, has virtually little side effects
Actions :
Analgesic action of Paracetamol is believed to be due to
inhibition of brain prostaglandin synthetase activity and through
a peripheral action by blocking pain impulse generation. The
peripheral action is also believed to be due to either inhibition
of prostaglandin synthesis or inhibition of actions or synthesis
of some other substances responsible for sensitizing pain
receptors to chemical or mechanical stimulation.
Antipyretic action of Paracetamol is believed to be due to its
action on the hypothalamic heat-regulating centre producing
peripheral vasodilatation and thus resulting in increased blood
flow through the skin, sweating and heat loss. This action
probably involves inhibition of prostaglandin synthetase activity
in the hypothalamus.
Indications : Paracetamol (tablets & syrup) is indicated in
fever associated with bacterial or viral infections, mild to
moderate pain including muscular pain, joint pains, sprains and
injuries, wryneck, toothache, headache, earache, neuralgia, post-immunisation
reaction, post tonsillectomy pain, menstrual discomfort,
discomforts of cold and flu, pharyngitis, laryngitis and
tracheobronchitis.
Adverse Reactions :
With normal therapeutic doses of Paracetamol hypersensitivity
reactions like erythematous or urticarial skin rashes, mucosal
lesions, drug, fever, etc. may occur rarely.
Precautions : Care should be taken for patients with impaired
liver or kidney functions
Drug Interactions :
Co-administration of alcohol and Paracetamol (paracetamol), at
least in high therapeutic doses, may be harmful. With
chloramphenicol, half-life of the antibiotic is prolonged which
may cause increased toxic effects of the antibiotic, probably due
to competitive metabolism that takes place between the two
compounds.
Packing :
Paracetamol Tablets : Strips of 10 tablets
Paracetamol Syrup : Phials 60 ml
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Quality
