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Each film coated tablet contains
Composition
Bupropion hydrochloride 150 mg
(As extended release
tablets).........................................150 mg
Indications
Nicotoxin is indicated for the treatment of depression. It is also
indicated as a smoking cessation treatment.
Description
Bupropion is a norepinephrine and dopamine uptake inhibitor that
has been available for several years for the treatment of
depression and aiding smokers to quit. Bupropion is an
antidepressant medication that affects chemicals within the brain
that nerves use to send messages to each other. These chemical
messengers are called neurotransmitters. The neurotransmitters
that are released by nerves are taken up again by the nerves that
release them for reuse. (This is referred to as reuptake.) Many
experts believe that depression is partly caused by an imbalance
among the amounts of neurotransmitters that are released.
Bupropion is unrelated to other antidepressants. It works by
inhibiting the reuptake of dopamine, serotonin, and norepinephrine,
an action which results in more dopamine, serotonin, and
norepinephrine to transmit messages to other nerves. Bupropion is
unique in that its major effect is on dopamine, an effect which is
not shared by the selective serotonin reuptake inhibitors or SSRIs
(e.g. paroxetine, Paxil; fluoxetine, Prozac; sertraline, Zoloft)
or the tricyclic antidepressants or TCAs (e.g. amitriptyline,
Elavil; imipramine, Tofranil; desipramine, Norpramin). Bupropion
hcl is available as sustained release bupropion SR.
Dosage
Adults: Initially, 150 mg once daily in the morning; titrate after
no less than 4 days to 150 mg twice daily if needed. The onset of
antidepressant effects takes 1–3 weeks, maximal effect may not be
noted for 4 weeks. The lowest dosage that maintains remission is
recommended.
Presentations
10 tablet
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Quality
