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Each tablet contains
Composition
Nimesulide.............................................................100
mg
Indications
Nimesulide is indicated in the treatment of a variety of painful
inflammatory conditions including those associated with
osteoarthritis, postoperative trauma, sports injuries, acute
musculoskeletal disorders including tendonitis, tenosynovitis,
sprains, strains and low back pain, ear, nose and throat
disorders, dental surgery, bursitis/tendonitis, thrombophlebitis,
pharyngitis and gynaecological disorders.
Description
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) of the
sulfonanilide class. Its anti-inflammatory, analgesic and
antipyretic activities have been demonstrated in several widely
used animal experimental models and in numerous clinical trials.
Nimesulide only weakly inhibits prostaglandin synthesis and
appears to exert its effects through various mechanisms. It
inhibits the release of oxidants from activated neutrophils and
has a scavenging effect on hypochlorous acid without affecting
neutrophil function. Nimesulide also decreases histamine release
from tissue mast cells and inhibits the production of
platelet-activating factor by human basophils. Furthermore, when
added in vitro to cultures of human articular chondrocytes,
nimesulide inhibits the release of stromelysin and blocks
metalloproteinase activity.
Contraindications
Active peptic ulcer disease. Moderate to severe hepatic
impairment. n patients who have previously shown a
hypersensitivity to it or nimesulide in any of its dosage forms.
Dosage
Usual oral dose of Nimesulide in adults is 100 mg twice daily.
Presentations
10 tablets
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Quality
