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Each tablet
contains :
Composition:
Atorvastatin……….........................................
10 mg
Atorvastatin……….........................................
20 mg
Indications :
Liposec is a
prescription drug. It is used in patients with multiple risk
factors for heart disease such as family history, high blood
pressure, age ,low HDL or smoking to reduce the risk of heart
attack and stroke. Liposec is also used in patients with type 2
diabetes and at least one other risk factor for heart disease such
as high blood pressure, smoking or complications of diabetes,
including eye disease and protein in urine, to reduce the risk of
heart attack and stroke.
Description:
Atorvastatin (Lipitor)
is a selective, competitive inhibitor of HMG CoA reductase, the
rate-limiting enzyme that converts 3-hydroxy
3-methylglutaryl-coenzyme A to mevalonate, a precursor of sterols,
including cholesterol. Cholesterol and triglyceridescirculate in
the bloodstream as party of lipoprotein complexes.With
ultracentrifugation, these complexes separate into HDL
(high-density lipoprotein), IDL (intermediate-density
lipoprotein), LDL (low-density lipoprotein), and VLDL
(very-low-density lipoprotein) fractions. Triglycerides (TG)
and cholesterol in the liver are incorporated into VLDL and
released into the plasma for delivery to peripheral tissues. LDL
is formed from VLDL and is catabolized primarily through the
high-affinity LDL receptor. Clinical and pathologicstudies wshow
that elevated plasma levels of total cholestero (total-C), LDL-cholesterol
(LDL-C), and apolipoprotein B (apo B) promote human
atherosclerosis and are risk factors for developing
cardiovascular disease, while increased levels of HDL-C are
associated with a decreased cardiovascular risk. In animal models,
Atorvastatin (Lipitor) lowers plasma cholesterol and
lipoprotein levels by inhibiting HMG-CoA reductase and
cholesterol synthesis in the liver and by increasing the number of
hepatic LDL receptors on the cell-surface to enhance uptake and
catabolism of LDL; Atorvastatin (Lipitor) also reduces LDL
production and the number of LDL particles. Atorvastatin (Lipitor)
reduces LDL-C in some patients with homozygous familial
hypercholesterolemia (FH), a population that rarely responds to
other lipid-lowering medication.A variety of clinical studies have
demonstrated that elevated levels of total-C, LDL-C, and apo B (a
membrane complex for LDL-C) promote human atherosclerosis.
Similarly, decreased levels of HDL-C (and its transport complex,
apo A) are associated with the development of atherosclerosis.
Epidemiologic investigations have established that cardiovascular
morbidity and mortality vary directly with the level of total-C
and LDL-C, and inversely with the level of HDL-C. Although
frequently found in association with low HDL-C, elevated plasma TG
has not been established as an independent risk factor for
coronary heart disease. The independent effect of of raising HDL-C
or lowering TG on the risk fro coronary and cardiovascular
morbidity and mortality has not been established. Atorvastatin (Lipitor)
reduces total-C, LDL-C, and apo B in patients with homozygous and
heterozygous FH, nonfamilial forms of hypercholesterolemia, and
mixed dyslipidemia. Atorvastatin (Lipitor) also reduces VLDL-C and
TG and produces variable increases in HDL-C and apolipoprotein
A-1. The effect of Atorvastatin (Lipitor) on cardiovascular
morbidity and mortality has not been determined.Like LDL,
cholesterol-enriched triglyceride-rich lipoproteins, including
VLDL, intermediate density lipoprotein (IDL), and remnants, can
also promote atherosclerosis. Elevated plasma triglycerides are
frequently found in a triad with low HDL-C levels and small LDL
particles, as well as in association with non-lipid metabolic risk
factors for coronary heart disease. As such, total plasma TG has
not consistently been shown to be an independent risk factor for
CHD. Furthermore, the independent effect of raising HDL or
lowering TG on the risk of coronary and cardiovascular morbidity
and mortality has not been determined.
Dosage:
As per the physician’s advice. |
Quality
