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Each soft gelatin vaginal suppositories contains
Composition
Clindamycin Phospphate BP
equivalent Clindamycin.............................100 mg
Clotrimazole I.P..........................................200 mg
Excipients......................................................q.s.
Indications
Infective leucorrhoea, mixed infections and non-specific vaginitis,
Vaginal Candidiasis bactorial vaginosis & Trichomonasis.
Description
It interferes with bacterial protein synthesis, by binding to the
50S subunit of the bacterial ribosome.
This causes antagonism if administered simultaneously and possible
cross-resistance.
Side effects
Adverse reactions associated with the use of clindamycin
phosphate gel include itching and peeling skin.
Cases of diarrhea, bloody diarrhea, and colitis have been reported
as adverse reactions in subjects treated with oral and parenteral
(intravenous) formulations of clindamycin, and have been reported
rarely with topical clindamycin. Abdominal pain and
gastrointestinal disturbances, as well as gram-negative
folliculitis (bacterial infection and inflammation of hair
follicles), have also been reported in association with the use of
topical formulations of clindamycin.
Directions for use
Wash hands thoroughly, before and after insertion of Gynasafe in
the vagina. The suppository should be inserted as deep as
possible. This is best achieved when lying on the back with legs
pulled in little towards the body. After the insertion of Gynasafe
no acitivity should be done such as standing, walking, running
etc; hence insert while retiring to bed. For best results, take
the complete therapy of 3 days. Do not discontinue in the middle.
Discontinue only if severe irritation is experienced, only after
consulting
Dosage & Administration
Suppositories should be inserted into the vagina for 3 consecutive
nights. Preferably before retiring to bed. Treatment should be
timed so as to avoid the menstrual period.
Presentations
3 Kit
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Quality
