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WARNING
Diaros ® may infrequently
cause or worsen certain heart problems (congestive heart failure,
heart attack). Seek immediate medical attention if you notice any
symptoms of heart problems, including: swelling of the hands/feet,
unusual/sudden weight gain, trouble breathing, chest
pain/discomfort.
USES
Diaros ® is a combination of
two drugs, rosiglitazone and glimepiride. It is used along with a
proper diet and exercise program to control high blood sugar in
patients with type 2 diabetes (non-insulin-dependent diabetes).
Effectively controlling high blood sugar helps prevent heart
disease, strokes, kidney disease, blindness, and circulation
problems, as well as sexual function problems (impotence).
Rosiglitazone-containing medications are best used only when other
medications (metformin) cannot be taken.
Rosiglitazone belongs to a class of drugs known as
thiazolidinediones or "glitazones". It works by helping to restore
your body's proper response to insulin, thereby lowering your
blood sugar.
Dosage
Diaros ® take by mouth,
usually once daily with the first meal of the day or as directed
by your doctor.
The dosage is based on your medical condition and response to
therapy. Do not take more than 8 milligrams of rosiglitazone/4
milligrams of glimepiride per day.
Use this medication regularly in order to get the most benefit
from it. Remember to take it at the same time each day. Monitor
your blood sugar levels on a regular basis, and share the results
with your doctor.
It may take up to 2-3 months before the full benefit of this drug
takes effect.
SIDE EFFECTS
Headache or sore throat may occur. If either of these effects
persist or worsen, notify your doctorThihis medication can cause
low blood sugar (hypoglycemia). This effect may occur if you do
not consume enough calories (from food, juices, fruit, etc.). The
symptoms include chills, cold sweat, blurred vision, dizziness,
drowsiness, shaking, rapid heart rate, weakness, headache,
fainting, tingling of the hands/feet, and hunger. It is a good
habit to carry glucose tablets or gel to treat low blood sugar. If
you are in a situation where you don't have these reliable forms
of glucose, eat a quick source of sugar such as table sugar,
honey, or candy, or drink a glass of orange juice or non-diet soda
to quickly raise your blood sugar level. Tell your doctor
immediately about the reaction. To help prevent hypoglycemia, eat
meals on a regular schedule and do not skip meals.
Symptoms of high blood sugar (hyperglycemia) include thirst,
increased urination, confusion, drowsiness, flushing, rapid
breathing, and fruity breath odor. If these symptoms occur, tell
your doctor immediately. Your medication dosage may need to be
increased.
A very serious allergic reaction to this drug is unlikely, but
seek immediate medical attention if it occurs. Symptoms of a
serious allergic reaction may include: rash, itching, swelling,
severe dizziness, trouble breathing.
PRECAUTIONS
This medication should not be used if you have certain medical
conditions. Before using this medicine, consult your doctor or
pharmacist if you have: type 1 diabetes (insulin-dependent
diabetes), very high blood sugar levels (diabetic ketoacidosis),
newly diagnosed or worsening heart failure (acute congestive heart
failure), history of liver disease, active liver disease.
Before using this medication, tell your doctor or pharmacist your
medical history, especially of: heart problems (e.g., chronic
congestive heart failure, heart attack, angina), fluid in your
lungs, swelling (edema, fluid retention), kidney disease, thyroid
problems, certain hormonal conditions (adrenal/pituitary
insufficiency, SIADH-syndrome of inappropriate secretion of
antidiuretic hormone), mineral imbalance (hyponatremia), anemia,
high blood cholesterol, eye (retina) problems, bone problems
(e.g., osteoporosis, osteopenia).
STORAGE
Store at room temperature at 77 degrees F (25 degrees C) away
from light and moisture. Brief storage between 59-86 degrees F
(15-30 degrees C) is permitted. Do not store in the bathroom.
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